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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-399-7 | CAS number: 140-11-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 220.4 mg/m³
- Explanation for the modification of the dose descriptor starting point:
As a repeated dose inhalation toxicity study is not available, the NOAEL from the oral 90 -day study in the rat was used to derive the modified dose descriptor starting point. A NOAEC of 220.4 mg/m³ was derived taking into account the respiratory volume of a rat and a worker for a relevant duration (/0.38*0.67) and the oral NOAEL of 250 mg/kg bw/d. In the absence of specific data, it was assumed that inhalation absorption is twice that of oral absorption.
- AF for dose response relationship:
- 1
- Justification:
- not required as starting point is a NOAEC
- AF for differences in duration of exposure:
- 2
- Justification:
- Sub-chronic to chronic exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required - already taken into account in modification of dose descriptor starting point
- AF for other interspecies differences:
- 2.5
- Justification:
- default ECHA value
- AF for intraspecies differences:
- 5
- Justification:
- default ECHA value for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Default for acceptable database
- AF for remaining uncertainties:
- 1
- Justification:
- No additional factor required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
In the absence of specific data, oral absorption is considered to be equivalent to dermal absorption.
- AF for dose response relationship:
- 1
- Justification:
- not required as starting point is a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Sub-chronic to chronic exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The starting point is derived from a study in the rat
- AF for other interspecies differences:
- 2.5
- Justification:
- default ECHA value
- AF for intraspecies differences:
- 5
- Justification:
- default ECHA value for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Default for acceptable database
- AF for remaining uncertainties:
- 1
- Justification:
- No additional factor required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Inhalation DNEL values
Systemic Long-term
The sub-chronic oral NOAEL of 250 mg/kg bw/d is corrected for the extent of inhalation absorption (100%) and oral absorption (50%) and breathing rate (/0.38 *0.67) to give a corrected (inhalation) starting point (NOAEC) of 220.4 mg/m³. Application of assessment factors of 1 (default value for dose-response relationship), 2 (for duration: extrapolation from a sub-chronic study to chronic exposure), 2.5 (for interspecies differences), 5 (for intraspecies differences; default values for workers), 1 (for database quality) and 1 (for remaining uncertainties) results in an overall assessment factor of 25. Application of the overall assessment factor to the corrected starting point gives a DNEL value of 9 mg/m³.
Systemic Acute/short-term
Benzyl acetate is of low systemic toxicity following oral exposures and is not classified for acute oral, dermal or inhalation toxicity. The substance is not corrosive or sensitising to the skin following dermal contact. Inhalation exposure is unlikely based on the physico-chemical properties of the test material. An acute systemic DNEL is therefore not required.
Local
Long term and short term local inhalation DNEL values are not proposed in the absence of any identified hazard.
Dermal DNEL values
Systemic Long-term
The long term systemic dermal DNEL value was derived from the dermal NOAEL of 250 mg/kg bw/d established in a 90 day study in rats; correction for route-to route extrapolation is not therefore required. The long term dermal DNEL value was derived using default ECHA assessment factors. Application of assessment factors of 1 (for dose response), 2 (extrapolation from a sub-chronic to chronic exposure), 4 (allometric scaling), 2.5 (additional interspecies differences) and 5 (intraspecies differences), 1 (for database quality) and 1 (for remaining uncertainties) results in an overall AF of 100 and a DNEL of 2.5 mg/kg bw/d. In the absence of specific data, oral and dermal absorption are assumed to be equivalent.
Systemic Acute/short-term
Benzyl acetate is of low systemic toxicity following oral exposures and is not classified for acute oral, dermal or inhalation toxicity. The substance is not corrosive or sensitising to the skin following dermal contact. An acute systemic DNEL is therefore not required.
Local
Long term and short term local inhalation DNEL values are not proposed in the absence of any identified hazard.
Eyes
No hazard is identified as benzyl acetate is not an eye irritant.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 108.7 mg/m³
- Explanation for the modification of the dose descriptor starting point:
As a repeated dose inhalation toxicity study is not available, the NOAEL from the oral 90 -day study in the rat was used to derive the modified dose descriptor starting point. A NOAEC of 108.7 mg/m³ was derived taking into account the respiratory volume of a rat (/1.15) and the NOAEL of 250 mg/kg bw/d. It was assumed that inhalation absorption is twice that of oral absorption.
- AF for dose response relationship:
- 1
- Justification:
- not required as starting point is a NOAEC
- AF for differences in duration of exposure:
- 2
- Justification:
- Sub-chronic to chronic exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required - already taken into account in modification of dose descriptor starting point
- AF for other interspecies differences:
- 2.5
- Justification:
- default ECHA value
- AF for intraspecies differences:
- 10
- Justification:
- default ECHA value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- Default for acceptable database
- AF for remaining uncertainties:
- 1
- Justification:
- No additional factor required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
In the absence of specific data, oral and dermal absorption are assumed to be equivalent.
- AF for dose response relationship:
- 1
- Justification:
- not required as starting point is a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Sub-chronic to chronic exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The starting point is derived from a study in the rat
- AF for other interspecies differences:
- 2.5
- Justification:
- default ECHA value
- AF for intraspecies differences:
- 10
- Justification:
- default ECHA value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- Default for acceptable database
- AF for remaining uncertainties:
- 1
- Justification:
- No additional factor required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Modification of the starting point is not required as it is derived from an oral study.
- AF for dose response relationship:
- 1
- Justification:
- not required as starting point is a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Sub-chronic to chronic exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The starting point is derived from a study in the rat
- AF for other interspecies differences:
- 2.5
- Justification:
- default ECHA value
- AF for intraspecies differences:
- 10
- Justification:
- default ECHA value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- Default for acceptable database
- AF for remaining uncertainties:
- 1
- Justification:
- No additional factor required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Inhalation DNEL values
Systemic Long-term
The sub-chronic oral NOAEL of 250 mg/kg bw/d is corrected for the extent of inhalation absorption (100%) and oral absorption (50%) and
breathing rate (/1.15) to give a corrected (inhalation) starting point (NOAEC) of 108.7 mg/m³. Application of assessment factors of 1 (default value for dose-response relationship), 2 (for duration: extrapolation from a sub-chronic study to chronic exposure), 2.5 (for interspecies differences), 10 (for intraspecies differences; default values for general population), 1 (for database quality) and 1 (for remaining uncertainties) results in an overall assessment factor of 50. Application of the overall assessment factor to the corrected starting point gives a DNEL value of 2.2 mg/m³.
Systemic Acute/short-term
Benzyl acetate is of low systemic toxicity following oral exposures and is not classified for acute oral, dermal or inhalation toxicity. The substance is not corrosive or sensitising to the skin following dermal contact. Inhalation exposure is unlikely based on the physico-chemical properties of the test material. An acute systemic DNEL is therefore not required.
Local
Long term and short term local inhalation DNEL values are not proposed in the absence of any identified hazard.
Dermal DNEL values
Systemic Long-term
The long term systemic dermal DNEL value was derived from the dermal NOAEL of 250 mg/kg bw/d established in a 90 day study in rats; correction for route-to route extrapolation is not therefore required. The long term dermal DNEL value was derived using default ECHA assessment factors. Application of assessment factors of 1 (for dose response), 2 (extrapolation from a sub-chronic to chronic exposure), 4 (allometric scaling), 2.5 (additional interspecies differences) and 10 (intraspecies differences), 1 (for database quality) and 1 (for remaining uncertainties) results in an overall AF of 200 and a DNEL of 1.3 mg/kg bw/d.
Systemic Acute/short-term
Benzyl acetate is of low systemic toxicity following oral exposures and is not classified for acute oral, dermal or inhalation toxicity. The substance is not corrosive or sensitising to the skin following dermal contact. An acute systemic DNEL is therefore not required.
Local
Long term and short term local inhalation DNEL values are not proposed in the absence of any identified hazard.
Oral DNEL values
Systemic Long-term
The long term systemic dermal DNEL value was derived from the dermal NOAEL of 250 mg/kg bw/d established in a 90 day study in rats; correction for route-to route extrapolation is not therefore required. The long term dermal DNEL value was derived using default ECHA assessment factors. Application of assessment factors of 1 (for dose response), 2 (extrapolation from a sub-chronic to chronic exposure), 4 (allometric scaling), 2.5 (additional interspecies differences) and 10 (intraspecies differences), 1 (for database quality) and 1 (for remaining uncertainties) results in an overall AF of 200 and a DNEL of 1.3 mg/kg bw/d.
Systemic Acute/short-term
Benzyl acetate is of low systemic toxicity following oral exposures and is not classified for acute oral, dermal or inhalation toxicity. The substance is not corrosive or sensitising to the skin following dermal contact. An acute systemic DNEL is therefore not required.
Eyes
No hazard is identified as benzyl acetate is not an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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