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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,4-trimethyl-4-phenyl-butane-nitrile
EC Number:
422-580-8
EC Name:
2,2,4-trimethyl-4-phenyl-butane-nitrile
Cas Number:
75490-39-0
Molecular formula:
C13 H17 N
IUPAC Name:
2,2-dimethyl-4-phenylpentanenitrile

Test animals

Species:
other: Rat (Sprague-Dawley)

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: Liquid substance applied undiluted.
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: No deaths occurred and no signs of systemic toxicity were observed.
Gross pathology:
Effects on organs:
No treatment-related macroscopic abnormalities were
observed.
Other findings:
Signs of toxicity (local):
No signs of irritation or other dermal changes, were
observed at application site.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU