Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 205-594-7 | CAS number: 143-24-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Received: 16 June 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test substance belongs to the homologue series of glymes. It can be assumed that each members exhibit comparable dermal penetration properties.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Deviations:
- yes
- Remarks:
- one concentration, skin not rinsed at termination
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-methoxyethyl) ether
- EC Number:
- 203-924-4
- EC Name:
- Bis(2-methoxyethyl) ether
- Cas Number:
- 111-96-6
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 1-methoxy-2-(2-methoxyethoxy)ethane
- Reference substance name:
- Diglyme
- IUPAC Name:
- Diglyme
- Reference substance name:
- 1,2-dimethoxyethane
- EC Number:
- 203-794-9
- EC Name:
- 1,2-dimethoxyethane
- Cas Number:
- 110-71-4
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 1,2-dimethoxyethane
- Reference substance name:
- Monoglyme
- IUPAC Name:
- Monoglyme
- Reference substance name:
- 1,2-Methoxyethane
- IUPAC Name:
- 1,2-Methoxyethane
- Details on test material:
- Supplier: Sigma Chemical Co., USA
Purity: 99%
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
- Radiolabelling:
- no
Test animals
- Species:
- human
- Strain:
- other: n.a.
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The donors were men under 60 years of age.
Administration / exposure
- Type of coverage:
- other: in vitro study
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 30, 60, 90, 120, 150, 180 and 240 min.
- Doses:
- 0.2 mL
- No. of animals per group:
- 8 runs, one per determined time point
- Control animals:
- no
- Remarks:
- in vitro study
- Details on study design:
- Please refer to "Details on in vitro test system"
- Details on in vitro test system (if applicable):
- In vitro skin permeation using human skin was measured with the Franz method.
Results and discussion
- Signs and symptoms of toxicity:
- not examined
- Remarks:
- in vitro study
- Dermal irritation:
- not examined
- Remarks:
- in vitro study
- Absorption in different matrices:
Lag time: 36 +/- 3 min for diglyme, 39 +/- 3 min for monoglyme
Flux at steady state permeation: 0.952 +/- 0.340 mg/cm2/h for diglyme, 3.434 +/- 1.897 mg/cm2/h for monoglyme
Permeation values of mixture (glycol ether 30% + acetone 70%)
Lag time: 49 +/- 28 min for diglyme, 35 +/- 27 min for monoglyme
Flux at steady state permeation: 0.674 +/- 0.305 mg/cm2/h for diglyme, 0.837 +/- 0.474 mg/cm2/h for monoglyme,- Total recovery:
- not determined
- Conversion factor human vs. animal skin:
- n.a.
Any other information on results incl. tables
Analogue approach justification (target chemical: tetraglyme; source chemicals: di- and monoglyme)
The target and the source chemical belong to the homologues series of glymes, where there is an incremental increase in the number of CH2CH2O units. The dermal penetration property of the target chemical is expected to be comparable to those of the proposed source chemicals, because the relevant physico-data (water solubility, LogPow) on target and source chemicals do not deviate significantly from each other. The molecular size of target chemical, althogh significantly higher than those of source chemicals, is still in the range indicative of higher skin penetration and is not likely to influence the skin penetration property significantly.
Applicant's summary and conclusion
- Conclusions:
- Tetraglyme is likely readily bioavailable upon dermal exposure.
- Executive summary:
Tetraglyme is expected to be readily bioavailable upon dermal application based on the read-across appraoch using di- and monoglyme as source chemicals.
An in vitro skin absorption study was performed applying diglyme to dermatomed human skin.
For diglyme, the lag time was reported to be 36 +/- 3 min and the flux at steady state permeation was 0.952 +/- 0.340 mg/cm2/h.
For monoglyme, the lag time was reported to be 39 +/- 3 min and the flux at steady state permeation was 3.434 +/- 1.897 mg/cm2/h.
Based on the obtained results, it can be concluded that diglyme and monoglyme are dermally readily bioavailable.
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