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EC number: 227-561-6 | CAS number: 5888-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2017-05-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Isobornyl acrylate and Isobornyl methacrylate are structurally very similar esters of the same alcohol moity (Isoborneol) and very similar acid moities (acrylic acid and methacrylic acid) with only difference is one additional methyl group in the structure of methacrylic acid in contrast to acrylic acid.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Purities of the target chemical Isobornyl acrylate and the read across substance Isobornylmethacrylate are in the same order:
The typical reactivee ster content of Isobornyl acrylate is > = 98.5 %
The analytical purity of the read across substance Isobornyl methacrylate in the adsorption/desorption test was 99.4 % (reactive ester content)
3. ANALOGUE APPROACH JUSTIFICATION
Adsorption/desorption correlates with log Kow of a substance.
Log Kow of the read across substance Isobornyl methacrylate is 5.09 and therefore higher than log Kow of the target substance Isobornyl acrylate (log Kow=4.52). A read across with Isobornyl methacrylate for the end point adsorptio/desorption would represent a worst case and is therefore justified.
4. DATA MATRIX
see attached justification- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Key result
- Type:
- log Koc
- Value:
- 3.71 dimensionless
- Temp.:
- 25 °C
- Remarks on result:
- other: HPLC-Merthod
- Validity criteria fulfilled:
- yes
- Conclusions:
- Log Koc of Isobornyl methacrylate was measuerd in OECD 121 Guideline , HPLC Method. Result. Log Koc=3.71
- Executive summary:
Adsorption/desorption of Isobornyl acrylate was assessed based on read across with Isobornyl methacrylate for which test data are available.
As adsorption/desorption correlates with log Kow of a substance and log Kow of the read across substance Isobornyl methacrylate is 5.09 and therefore higher than log Kow of the target substance Isobornyl acrylate (log Kow=4.52), a read across with Isobornyl methacrylate for the end point adsorption/desorption would represent a worst case and is therefore be justified.
Log Koc of Isobornyl methacrylate was measured in OECD 121 Guideline test, HPLC Method. Result. Log Koc=3.71. Log Koc of Isobornyl acrylate is expected to be in the same order or slightly lower.
As the predicted log Koc is lower than the trigger value of 4, a high potential of adsorption to soil and sediment is not expected.
Reference
Determination of the dead timet0
Dead time marker |
tR/min 1 st Measurement |
tR/ min 2 nd Measurement |
tR/min Mean |
Formamide |
1.708 |
1.708 |
1.708 |
Dead time to = 1.71
Calibration data-1stmeasurement
Calibration substance |
1st lnj. tR/min |
k |
log |
logKoca |
Acetanilide |
2.168 |
0.27 |
-0.57 |
1.25 |
Atrazin |
2.603 |
0.52 |
-0.28 |
1.81 |
Triadimenol |
3.568 |
1.09 |
0.04 |
2.40 |
Linuron |
4.115 |
1.41 |
0.15 |
2.59 |
Pyrazophos |
7.325 |
3.29 |
0.52 |
3.65 |
Diclofop-methyl |
10.279 |
5.02 |
0.70 |
4.20 |
4,4' DDT |
34.548 |
19.23 |
1.28 |
5.63 |
|
|
|
|
|
Regression:1ogK0c=a+b·logk
Parameters:
a 2.444
b = 2.408
r2= 0.9919
logK0c ofthe test item-1stmeasurement
Testltem |
1st lnj. tR/min |
k |
log |
logKoca |
Isobornyl methacylate |
7.567 |
3.43 |
0.54 |
3.73 |
Calibration data-2 ndmeasurement
Calibration substance |
1st lnj. tR/min |
k |
log |
logKoca |
Acetanilide |
2.174 |
0.27 |
-0.56 |
1.25 |
Atrazin |
2.609 |
0.53 |
-0.28 |
1.81 |
Triadimenol |
3.566 |
1.09 |
0.04 |
2.40 |
Linuron |
4.135 |
1.42 |
0.15 |
2.59 |
Pyrazophos |
7.338 |
3.30 |
0.52 |
3.65 |
Diclofop-methyl |
10.427 |
5.10 |
0.71 |
4.20 |
4,4' DDT |
35.638 |
19.87 |
1.30 |
5.63 |
|
|
|
|
|
Regression:1ogK0c=a+b·log k
Parameters:
a =2.435
b = 2.397
r2= 0.9926
logK0c ofthe test item-2 ndmeasurement
Testltem |
1st lnj. tR/min |
k |
log |
logKoca |
Isobornyl methacylate |
7.510 |
3.40 |
0.53 |
3.71 |
Result: mean adsorption coefficient logKoc of 3.7.
Description of key information
Adsorption/desorption of Isobornyl acrylate was assessed based on read across with Isobornyl methacrylate for which test data are available.
As adsorption/desorption correlates with log Kow of a substance and log Kow of the read across substance Isobornyl methacrylate is 5.09 and therefore higher than log Kow of the target substance Isobornyl acrylate (log Kow=4.52), a read across with Isobornyl methacrylate for the end point adsorption/desorption would represent a worst case and is therefore be justified.
Log Koc of Isobornyl methacrylate was measured in OECD 121 Guideline test, HPLC Method. Result. Log Koc=3.71. Log Koc of Isobornyl acrylate is expected to be in the same order or slightly lower.
As the predicted log Koc is lower than the trigger value of 4, a high potential of adsorption to soil and sediment is not expected.
Key value for chemical safety assessment
- Koc at 20 °C:
- 3.71
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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