Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-899-1 | CAS number: 75-76-3
Endpoint summary
Administrative data
Description of key information
A combined repeat dose inhalation toxicity study and reproductive/developmental toxicity screening study was carried out for tetramethylsilane according to OECD 422 and in compliance with GLP (DCC, 2005). There were no adverse effects on general systemic, reproductive or developmental endpoints at the highest dose tested, 5000 ppm (ca. 18,000 mg/m3).
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 5 000
- Study duration:
- subacute
- Species:
- rat
Additional information
The key study for repeated dose toxicity is the only available study for this endpoint. The study was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP, and was therefore assigned Reliability 1. A range-finding study is also available.
Justification for classification or non-classification
There are no data to suggest that tetramethylsilane should be classified for specific target organ toxicity following repeated exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Route: .live2