Registration Dossier
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EC number: 200-899-1 | CAS number: 75-76-3
Endpoint summary
Administrative data
Description of key information
A combined repeat dose inhalation toxicity study and reproductive/developmental toxicity screening study was carried out for tetramethylsilane according to OECD 422 and in compliance with GLP (DCC, 2005). There were no adverse effects on general systemic, reproductive or developmental endpoints at the highest dose tested, 5000 ppm (ca. 18,000 mg/m3).
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 5 000
- Study duration:
- subacute
- Species:
- rat
Mode of Action Analysis / Human Relevance Framework
Additional information
The key study for repeated dose toxicity is the only available study for this endpoint. The study was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP, and was therefore assigned Reliability 1. A range-finding study is also available.
Justification for classification or non-classification
There are no data to suggest that tetramethylsilane should be classified for specific target organ toxicity following repeated exposure.
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