Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-666-8 | CAS number: 2855-13-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: sewage treatment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-07-07 to 1992-08-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: Distinction between elimination by biodegradation and by adsorption not possible
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 303 A (Simulation Test - Aerobic Sewage Treatment. A: Activated Sludge Units)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-aminomethyl-3,5,5-trimethylcyclohexylamine
- EC Number:
- 220-666-8
- EC Name:
- 3-aminomethyl-3,5,5-trimethylcyclohexylamine
- Cas Number:
- 2855-13-2
- Molecular formula:
- C10H22N2
- IUPAC Name:
- 3-(aminomethyl)-3,5,5-trimethylcyclohexan-1-amine
Constituent 1
- Radiolabelling:
- no
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- INOCULUM/TEST ORGANISM
- Source: municipal WWTP Marl-West, sampled 07 Jul 1992
- Pretreatment: fed into test apparatus ca. 40 min after sampling - Duration of test (contact time):
- 6 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 15.9 mg/L
- Based on:
- test mat.
- Initial conc.:
- 10.1 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST SYSTEM
- Culturing apparatus: flow-through (3 l; 0.5 l/h) - Number of culture flasks per concentration: 1 - Aeration device: pump
- Composition of synthetic waste water: 88 mg/l Pepton (Unipath) 55 mg/l meat extract (Unipath) 15 mg/l urea, CAS RN 57-13-6 3.5 mg/l sodium chloride p.a., CAS RN 7647-14-5 2 mg/l calcium chloride x 2 H2O p.a. 1 mg/l magnesium sulfate x 7 H2O p.a. 14 mg/l K2HPO4 p.a. 98 mg/l NaHCO3 (Ferak) -
Additional nutrition substrate A: 32 g/l Pepton 22 g/l meat extract 6 g/l urea 1.4 g/l sodium chloride 0.8 g/l calcium chloride x 2 H2O 0.4 g/l magnesium sulfate x 7 H2O substrate B
- 33.5 g/l K2HPO4 is stored separately - 47 g/l NaHCO3 is stored separately
- 5 ml K2HPO4 soln. + 25 ml NaHCO3 soln + 11 l tap water This soln. and nutrition substrate A (30 ml/l) are added separately
- Duration of the test:: 31 days
- Test temperature: 21.8-26.2 degree C - Other relevant factors: mean retention time 6 hours
Reference substance
- Reference substance:
- not required
Results and discussion
% Degradation
- % Degr.:
- 42
- Parameter:
- DOC removal
- Sampling time:
- 31 d
- Transformation products:
- not measured
- Evaporation of parent compound:
- not measured
- Volatile metabolites:
- not measured
- Residues:
- not measured
- Details on results:
- The mean of 19 measurements at approximately regular intervals is 42.0 +/- 5.01 % degradation
Applicant's summary and conclusion
Validity criteria
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The present study indicates that a certain amount (ca. 42 %) of the test substance may degrade in the sewage treatment plant.
- Executive summary:
The present study on isophorone diamine simulates the degradation of the test substance in a sewage treatment plant and is similar or equivalent to OECD 303. The simulation study indicates that 42 % of the test item degraded within a period of 31 days. The study was assessed as "reliable with restrictions".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1