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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
according to company guideline, but limited documentation
Principles of method if other than guideline:
UV-Vis analysis of test substance solutions in DMSO and in 1,2-propylene glycol after stirring for 72 hours at room temperature
Test substance stable:
yes

The test substance is more than 72 hours stable and homogeneous in DMSO and in 1,2.propylene glycol at room temperature.

Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
The stability of a substance in organic solvents is a question of the chemical structure rather than a question of particle size. Whether any chemical reaction might take place is determined by the functional groups present in the molecule. It has been shown, that the bulk form is stable and read-across to the nanoform is reasonably justified.
Reason / purpose for cross-reference:
read-across source
Test substance stable:
yes
Conclusions:
At room temperature, the test substance is stable and homogeneous for more than 72 hours in DMSO (0.1 and 50 mg/mL) and in1,2 -propylene glycol (0.1 and 50 mg/mL).

Description of key information

The test substance is more than 72 hours stable and homogeneous in DMSO and in 1,2.propylene glycol at room temperature.

Additional information