Registration Dossier
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EC number: 293-054-1 | CAS number: 91051-05-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
There are no studies available on the toxicity of Fatty acids essential, Et esters (CAS 91051 -05 -7) to algae. The assessment was therefore based on studies conducted with the structurally most similar category members, for which data is available, Ethyl linoleate (CAS 544-35-4) and Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl esters (CAS 85049-37-2),, as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
The effects of Ethyl linoleate to the freshwater algae Pseudokirchneriella subcapitata were investigated in the read-across study. The study was performed according to OECD 201 and to GLP in concentrations up to 100 mg/L (ranges of 0.46 to 10 mg/L in the first main test and 1.0 to 100 mg/L in the second main test). The substance was tested as WAF (24 h stirring, 1 h settling period, siphoned through a glass tube containing glass-wool), where solutions <1 mg/L were diluted from the 1 mg/L filtrate. In the first test series, an 8.0 % reduction at 10 mg/L and a 33.2 % inhibition of yield were found (without statistical analysis). In the second test series, a 10.0 % reduction was found at 100 mg/L for growth rate and a 37.9 % inhibition of yield (both significant according to the Bonferroni test). In conclusion, the ErC50(72h) exceeds 100 mg/L (nominal). A NOECr(72h) is indicated at 32 mg/L (nominal), however, presumably based on effects of oversaturated test solutions indicated by the haziness/turbidity of the test concentrations. In the second main test, a slight haziness was observed directly after preparation of the test solutions of 32 and 100 mg/L. Furthermore, at 48h and 72 h, the cell density was determined via counting chamber, since a spectrophotometric measurement became impossible due to the turbidity in the test vessels.
In a supporting (marine) study, a read-aross from the substance Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl esters (CAS 85049-37-2), the marine alga Skeletonema costatum was tested according to ISO 10253 (WAF-test). The resulting EC50(72h) was determined as 281.4 mg/L (nominal, Hudson 2000).
Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on algae are expected up to the limit of water solubility for Fatty acids, essential, Et esters (CAS 91051-05-7).
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