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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association
Deviations:
no
Principles of method if other than guideline:
Method: other
GLP compliance:
not specified
Test type:
fixed dose procedure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Sample# bl 1636

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Remarks:
other
Doses:
500 mg per kg of body weight
No. of animals per sex per dose:
5 male and 5 female
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 500 mg/kg bw
Mortality:
no mortality
Body weight:
Sex Initial Final Change
M 203 g 292 g + 89 g
F 178 g 228 g + 50 g
Gross pathology:
Necropsy of all animals following sacrifice revealed at the end of the 14-day post-dose observation period, no gross pathological changes that could be attributed to administration were observed.

Any other information on results incl. tables

RS-Freetext:
All animals survived, showed no abnormal clinical signs and
gained weight.  Gross necropsy did not reveal any test
material-related pathological changes.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The oral administration to rats of 500 mg of Surfynol 104 per kg of body weight resulted in no mortality.
Accordingly, the submitted test material is not considered a toxic material orally, under the definition set forth by the
Manufacturing Chemist´s Association.
Executive summary:

The oral administration to rats of 500 mg of Surfynol 104 per kg of body weight resulted in no mortality.

Accordingly, the submitted test material is not considered a toxic material orally, under the definition set forth by the

Manufacturing Chemist´s Association.