Registration Dossier

Administrative data

Description of key information

There are no specific neurotoxicity data on any of the streams within the Resin Oils and Cyclic Dienes category. Of the specific components toluene and styrene are recognised as having neurotoxic activity.  These effects are discussed in the section on repeated dose toxicity (5.6.3).

Key value for chemical safety assessment

Additional information

Toluene exposure can produce central nervous system pathology in animals after high oral doses. In humans neuropsychological effects have been reported, particularly when exposures are not well controlled. There was no evidence that long-term exposure to toluene at 26 ppm for 21 years had any effects on cognitive function (Seeber et al, 2004). Inhalation exposure to styrene in animals produces impaired nerve conduction velocity.

Justification for classification or non-classification

See section 5.6 for overall classification for repeated dose toxicity.