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EC number: 270-790-1 | CAS number: 68478-10-4 A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Details on test material:
- - Name of test material (as cited in study report): Dicyclopentadiene/Codimer Concentrate
- Synonyms: DCPD/Codimer Concentrate, DCP97, H-25430
- CA Index name: Naphtha (petroleum), light steam-cracked, debenzenized, C8-16-cycloalkadiene concentrate
- Lot number: 121302
- Substance type: a distillate from a C8+ fraction of thermally processed pyrolysis gasoline obtained from ethylene production
- Physical state: colourless liquid
- Purity: Not applicable (The test substance was within specifications and the occurrence and distribution of isomers was as expected).
- Stability under test conditions: stable at room temperature below 70°F, protected from light and air
- Composition of test material, percentage of components:
29.175 wt % endo- and exo-DCPD
18.726 wt % C4-MCPD and C5-MCPD codimers
13.210 wt % MCPD dimer
12.903 wt % CPD-MCPD codimer
8.129 wt % C8 aliphatic and aromatic hydrocarbons
7.144 wt % C4-CPD and C5-CPD codimers
3.625 wt % MCPD-C7 dimer
2.771 wt % Tetrahydroindene
1.917 wt % Trimers
0.927 wt % C7 cyclic hydrocarbon
0.697 wt % C5 acyclic hydrocarbon dimer
0.634 wt % MCPD monomer
0.078 wt % CPD monomer
0.063 wt % C6 acyclic hydrocarbons
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 from Aroclor induced rat liver
- Test concentrations with justification for top dose:
- 15, 50, 150, 500, 1500 and 5000 µg per plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: ethanol
Controls
- Negative solvent / vehicle controls:
- yes
- Remarks:
- ethanol
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene, 2-nitrofluorene, sodium azide, 90aminoacridine, methyl methanesulfonate
- Remarks:
- +S9: All S.typh strains 1 µg/plate, E.coli 10 µg/plate. -S9: S. typh TA98 2-nitrofluorene 1 µg/plate, TA100 and TA1535 sodium azide 1 µg/plate, TA1537 9-aminoacridine 75 µg/plate, E.coli methyl methanesulfonate 1000 µg/plate
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 48-72 hours
NUMBER OF REPLICATIONS: 3
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth - Evaluation criteria:
- For each replicate plating, the mean and SD of the number of revertants/plate were counted. For a positive result, there must be a dose-related increase in the mean revertants/plate of at least one tester strain over a minimum of 2 increasing concentrations of test substance. Data sets for TA1535 and TA1537 were judged positive if the increase in mean revertants at the peak of the dose response ≥ 3 times the mean vehicle control value. Data sets for TA98, TA100 and WP2uvrA were positive if the increase in mean revertants at the peak of the dose response ≥ 2 times mean vehicle control value.
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- some conditions beginning at 667, 1000 or at 5000 µg/plate
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- some conditions beginning at 667, 1000 or at 5000 µg/plate
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results:
negative with metabolic activation
negative without metabolic activation
Dicyclopentadiene/codimer concentrate did not cause a positive response in either the presence or absence of Aroclor-induced rat liver S9. - Executive summary:
Dicyclopentadiene/codimer concentrate was tested in a bacterial reverse mutation test using Salmonella typhimurium tester strains TA98, TA100, TA1535 and TA1537 and Escherichia coli tester strain WP2 uvrA in the presence and absence or Aroclor-induced rat liver S9.
In the mutagenicity test, no positive mutagenic response was observed. The dose levels tested were 15, 15, 150, 500, 1500 and 5000 ug/plate. Toxicity was seen with some concentrations starting at 1500 or at 5000 ug/plate. No precipitate was observed.
It is concluded that dicyclopentadiene/codimer concentrate (CAS 68478-10-4) did not cause a positive response in either the presence or absence of Aroclor-induced rat liver S9 and is considered not to be mutagen in this test system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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