Registration Dossier
Registration Dossier
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EC number: 237-159-2 | CAS number: 13674-87-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Data for the oral route of exposure is not quantifiable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Objective of study:
- absorption
- distribution
- Principles of method if other than guideline:
- Fyrol FR-2 was administered by oral intubation at 3 different concentrations, following administration, the animals were held in individual metabolism.
- GLP compliance:
- no
Test material
- Details on test material:
- - Test substance purity not stated
- Radioactively labelled TDCP ([1,3-(14)C]2-propyl, specific activity 12.5mCi/mmol, radiochemical purity >99%)
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- carbon -14
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: NIEHS breeding colony
- Weight at study initiation: 150-200 g
- Individual metabolism cages: yes
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Emulphor:ethanol:water (1:1:8)
- Duration and frequency of treatment / exposure:
- Duration appears to be 24h, treatment is once-off
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2, 2 and 20 umol/kg (corresponding to 86ug/kg, 860ug/kg and 8.6mg/kg)
- No. of animals per sex per dose / concentration:
- At least three rats per dose
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Absorption from the GI tract was >90% within 24h (the report does not detail how this was measured)
- Details on distribution in tissues:
- After 24h the pattern of distribution is Kidney > Liver > Lung > Blood > Muscle.
- Details on excretion:
- No information was provided on excretion.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
