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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1981
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Data for the oral route of exposure is not quantifiable.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1981

Materials and methods

Objective of study:
absorption
distribution
Principles of method if other than guideline:
Fyrol FR-2 was administered by oral intubation at 3 different concentrations, following administration, the animals were held in individual metabolism.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Test substance purity not stated
- Radioactively labelled TDCP ([1,3-(14)C]2-propyl, specific activity 12.5mCi/mmol, radiochemical purity >99%)
Radiolabelling:
yes
Remarks:
carbon -14

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: NIEHS breeding colony
- Weight at study initiation: 150-200 g
- Individual metabolism cages: yes

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: Emulphor:ethanol:water (1:1:8)
Duration and frequency of treatment / exposure:
Duration appears to be 24h, treatment is once-off
Doses / concentrations
Remarks:
Doses / Concentrations:
0.2, 2 and 20 umol/kg (corresponding to 86ug/kg, 860ug/kg and 8.6mg/kg)
No. of animals per sex per dose:
At least three rats per dose
Control animals:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Absorption from the GI tract was >90% within 24h (the report does not detail how this was measured)
Details on distribution in tissues:
After 24h the pattern of distribution is Kidney > Liver > Lung > Blood > Muscle.
Details on excretion:
No information was provided on excretion.

Metabolite characterisation studies

Metabolites identified:
not measured

Applicant's summary and conclusion