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EC number: 428-710-1
CAS number: 207574-76-3
Test item is a white powder at 20 °C and 1013 hPa. There is no hazard
associated with the physical state. However, the test item is produced
in-situ, i.e. diluted in a solvent, and does not exist in its solid
form. It is produced and used in its dissolved form and, hence, there is
no chance of inhalative exposure to particles of the test item during
the entiry life cycle. A more detailed assessment regarding inhalative
hazards is given below.
As the test item decomposes before boiling, the boiling point cannot be
determined. There is no hazard resulting from decomposition of the test
item before boiling.
Results are summarised in the following table.
Since the biggest part of all particles with a diameter of about 0.5 -5
µm is deposited in the nasal cavity and laryngeal region of the
respiratory tract of humans1), most of the test item
particles are not able to penetrate deep into the alveolar regions.
Clearance of inhaled particles, if any, predominantly takes place by
mucocilia transport. Due to the fact that the test item did not show any
signs of toxicity in any toxicity study performed, acute oral toxicity
as well as repeated dose toxicity, it can be cloncluded that the
clearance of inhaled particles, if any, via the gastro-intestinal route
does not pose any hazard to human health. Therefore, the particle size
distribution does not result in any hazard.
Moreover, the test item is produced in-situ, i.e. diluted in a solvent,
and does not exist in its solid form. It is produced and used in its
dissolved form and, hence, there is no chance of inhalative exposure to
particles of the test item during the entiry life cycle.
1): Marquardt, Schäfer, "Lehrbuch der Toxikologie", 2.
Auflage, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, Germany
The vapour pressure of the test substance was determined to be < 2.35 x
10EXP-24 Pa, i.e. extremely low. Since volatilisation of the substance
is a function of its vapour pressure, it can be concluded that the test
item will not become airborne under any conditions relevant for its
production and use durings its entire life cycle. As a consequence, no
relevant release into the atmosphere will take place. Moreover, exposure
via the inhalative route will not occur for both workers as well as
The high LogPow values estimated reflect the extreme low water
solubility of the test item. Since the reason for the high Log Pow is
the poor water solubility, Log Pow cannot be directly associated with a
high lipophilicity and hence a possible tendency to bioaccumulate of the
test item. Further details on bioavailability
The fact that the test item is insoluble has direct effects on (i) the
n-octanol/water partition coefficient (Log Pow), (ii) biodegradation,
and (iii) adsorption properties as detailed in IUCLID5 sections 4.7,
5.2.1, and 5.4.1, respectively.
n-octanol/water partition coefficient (IUCLID5 section 4.7):
The Log Pow determined is between 12 and 16, i.e. extremely high,
reflecting the inability of the test item to dissolve in water.
Biodegradation (IUCLID5 section 5.2.1):
The test item is not biodegradable due to the fact that it is not
dissolved in water and, as a consequence, not bioavailable for
microorganisms. The fact that the test item is not bioavailable is also
supported by the results of the toxicological studies performed, as
summarised in the toxicokinetic assessment (cf. IUCLID5 section 7.1.1).
Adsorption/desorption (IUCLID5 section 5.4.1):
The adsorption coefficient was determined to be > 10, reflecting the
tendency of the test item to avoid any aqueous environment.
The test item does not give rise to any concern related to
auto-flammability. Neither did the study results indicate any hazard nor
does the molecule contain any structural alerts with respect to
pyrophoricity, explosive and oxidising properties.
The test item does not give rise to any concern related to flammability.
Neither did the study results indicate any hazard nor does the molecule
contain any structural alerts with respect to pyrophoricity, explosive
and oxidising properties. The test item does is not self-heating nor
does it react with water or air. Practical experience from production
and use do not give rise to any concern related to physical-chemical
The appraisal of the composition and the molecular structure
indicates without doubt, that the reactive groups in the
structural formula of the substance could not lead to the
conclusion, that the substance is capable of a rapid
decomposition or reaction with a strong release of heat.
This result was confirmed in analogy and extrapolation from
data existing for comparable components. Moreover, practical experience
from production and use do not give rise to any concern related to
The test substance does not have the functional groups associated with
oxidising activity. It has never demonstrated such activity under normal
handling. The oxygen balance of the test substance is negative. This
means, there is a surplus on carbon atoms.
Therefore, it can be concluded beyond reasonable doubt that the test
substance is incapable of causing fire or enhance the risk of fire when
in contact with combustible material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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