Registration Dossier
Registration Dossier
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EC number: 203-686-1 | CAS number: 109-60-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reliability score "2" adopted from OECD SIDS, restrictions: purity unknown, limited documentation, open coverage
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- A volume of 0.5 ml n-propyl acetate was applied to the clipped, abraded skin of 4 rabbits. Application sites (one each on left and right of each
animals) were examined after 72 hours for evidence of irritation. - GLP compliance:
- no
Test material
- Reference substance name:
- Propyl acetate
- EC Number:
- 203-686-1
- EC Name:
- Propyl acetate
- Cas Number:
- 109-60-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- propyl acetate
- Details on test material:
- Purity unknown
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male & female animals were used; no further data
ENVIRONMENTAL CONDITIONS
not reported
Test system
- Type of coverage:
- open
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- not reported
- Observation period:
- 72 h
- Number of animals:
- 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- other: very slight erythema observed
- Irritation parameter:
- erythema score
- Basis:
- animal: #2 - #4
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- < 1
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- Mean erythema score less than 1 based on assessment of reported results.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- Mean erythema score less 0 based on assessment of reported results.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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