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EC number: 203-457-6 | CAS number: 107-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: - scientifically sound study - limited reporting, non-GLP - no substance purity information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only two animals tested, only 0.0447 mL applied instead of 0.1 mL
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Allylchlorid, BAS 480 F
- Physical state: not reported
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Purity test date: not reported
- Lot/batch No.: 23469-77BD
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported, but expected to be stable
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 42 mg = 0.0447 mL
- Concentration (if solution): 100 %- Duration of treatment / exposure:
- treatment once without washout
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 2, one male, one female
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: Scoring system according to Kay and Calandra (Kay, J.H. & Calandra, J.C. (1962) Interpretation of eye irritation tests. J. Soc. Cosmet. Chem. 13, 281–289. )
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of both animals
- Time point:
- other: 1 h post treatment
- Score:
- 1.5
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: see table 1 for individual animal data
- Irritant / corrosive response data:
- A slight to moderate reddening of the conjunctiva 1 h after the treatment was the only sign of an adverse effect. The effect was fully reversible within the first 24 h after the treatment in both animals.
- Other effects:
- no
Any other information on results incl. tables
- Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Cornea |
Cornea |
Iris |
Conjunctivae |
||
Opacity Max. score: 4 |
Area involved Max. score: 4 |
Max. score: 2 |
Redness Max. score: 3 |
Chemosis Max. score: 4 |
Discharge Max. score: 4 |
|
Animal 0083 (male) |
|
|
|
|
|
|
60 min |
0 |
0 |
0 |
1 |
0 |
0 |
24 h |
0 |
0 |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
Average 24h, 48h, 72h |
0 |
0 |
0 |
0 |
0 |
0 |
Maximum average score (including area affected, max 110) |
0 |
0 |
0 |
0 |
0 |
0 |
Reversibility*) |
- |
- |
- |
c |
- |
- |
Average time (unit) for reversion |
- |
- |
- |
24 h |
- |
- |
Animal 0086 (female) |
|
|
|
|
|
|
60 min |
0 |
0 |
0 |
0 |
0 |
0 |
24 h |
0 |
0 |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
Average 24h, 48h, 72h |
0 |
0 |
0 |
0 |
0 |
0 |
Maximum average score (including area affected, max 110) |
0 |
0 |
0 |
0 |
0 |
0 |
Reversibility*) |
- |
- |
- |
c |
- |
- |
Average time (unit) for reversion |
- |
- |
- |
24 h |
- |
- |
*) Reversibility: c. = completely reversible;= not completely reversible; n. = not reversible
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- 3-Chloropropene was tested for its potency to cause eye irritation in an in vivo test in rabbits according to OECD 405 using 0.0447 mL of substance. The only effect noted was a slight to moderate reddening of the conjunctiva 1 h after the treatment in both animals that was fully reversible within 24 h. No other effects were reported. The applied amount is only 44,7 % of the amount stated in the guideline. As the effects reported are minimal and reversible within 24 h it can reasonably be assumed that even at a dose of 0.1 mL effects that would trigger a classification would not be seen. Based on these results the test item is not irritating to the eye in this test system and a classification for eye irritation according to CLP is not necessary.
- Executive summary:
In the present study (BASF 1990) 3-Chloropropene was tested for its potency to cause eye irritation in an in vivo test in rabbits according to OECD 405 using 0.0447 mL of substance. The only effect noted was a slight to moderate reddening of the conjunctiva 1 h after the treatment in both animals that was fully reversible within 24 h. No other effects were reported. The applied amount is only 44.7 % of the amount stated in the guideline. As the effects reported are minimal and reversible within 24 h it can reasonably be assumed that even at a dose of 0.1 mL effects that would trigger a classification would not be seen. Based on these results the test item is not irritating to the eye in this test system and a classification for eye irritation according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) is not necessary.
Animals were treated with 0.0477 mL (instilled into the right eye) of the undiluted test item. The treated eyes were not subsequentially rinsed. Irritating effects to the eye were scored at 60 min, 24, 48 and 72 h after the treatment according to the Score System by Kay and Calandra (Scoring system according to Kay and Calandra (Kay, J.H. & Calandra, J.C. (1962) Interpretation of eye irritation tests. J. Soc. Cosmet. Chem. 13, 281–289. ). As the initially developed slight to moderate reddening of the conjunctiva in both animals was fully reversible within 24 h the test was stopped 72 h after the start of treatment. Only two animals were treated, but as the effect is minimal and the results unequivocal, the test is judged to be reliable except for the uncertainty on substance purity.
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