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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Due to major deficiencies in presentation of the data the study is considered to be not valid

Data source

Reference
Reference Type:
publication
Title:
Die biologische Wirkung von Propionaldehyd und Propionsaeure auf den Organismus von Versuchstieren
Author:
Melnikowa AP and Tokanowa SE
Year:
1983
Bibliographic source:
Gig.Sanit. 4, 74-76 (1983) german translation

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Propionsaeure
- Source:
- Analytical purity:

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: adult (no further data)
- Weight at study initiation: 140 -160 g
- Fasting period before study:
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS: no data

Administration / exposure

Route of administration:
inhalation
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 months
Frequency of treatment:
"continuous exposure"
Doses / concentrations
Remarks:
Doses / Concentrations:
0.017, 0.17 und 1.7 mg/m3
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Examinations

Observations and examinations performed and frequency:
CAGE SIDE OBSERVATIONS: Yes
- Time schedule: no data
- Cage side observations checked: general state, behaviour

BODY WEIGHT: Yes
- Time schedule for examinations: no data

HAEMATOLOGY: Yes
- Time schedule for collection of blood: no data
- Parameters checked: leucocyte number, erythrocyte number, hemoglobin

CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: no data
- Parameters checked: cholinesterase
Sacrifice and pathology:
GROSS PATHOLOGY: Yes (organ weights were also taken. No data which organs were weighed)
HISTOPATHOLOGY: Yes
- Organs prepared: heart, lungs, liver, kidneys and spleen

Results and discussion

Results of examinations

Details on results:
Changes in lung tissue, bronchitis, peribronchitis, desquamation. The rather poor presentation of further systemic effects is not usable.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion