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EC number: 246-771-9
CAS number: 25265-77-4
dermal irritation study, three New Zealand White rabbits were each
administered 0.5 mL of undiluted Nesterol to the clipped skin of the
back for four hours under semiocclusion. The
animals were then observed for a total of 14 days for signs of primary
irritation (erythema and edema). During
the observation period, the test substance caused very slight to
well-defined erythema in three animals accompanied by very slight edema
in one animal. Dryness
and sloughing of the skin was noted in two animals starting on day 6 or
7 to day 13 when the skin of all animals was perceived as normal. Under
the study conditions, Nesterol is classified as a mild irritant in New
Zealand White Rabbits.
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