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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 22 and 24 January 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Method C2, Directive 92/69/EEC
- Principles of method if other than guideline:
- Groups of twenty, first instar Daphnia, less than 24 hours old, were exposed to UK-143, 108 for 48 hours at nominal concentrations of 1.0, 2.2, 4.6, 10, 22, 46 and 100 mg/I dissolved in Elendt M4 medium. The numbers of immobilised daphnids were recorded for each test and control group after 24 and 48 hours and the following values were determined. All results are expressed in terms of nominal concentration
- GLP compliance:
- yes
Test material
- Details on test material:
- Intended use: Pharmaceutical intermediate
Appearance: White to off-white powder
Storage conditions: Room temperature in the dark
Expiry date: Not supplied
Purity: 101.3%
Date received: 2 October 1996
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
N/A
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Test concentrations were verified by chemical analysis. Samples, 50 ml, were taken from the pooled replicates of control and each test concentration at 0 hours and after 48 hours and were sent to the Huntingdon Life Sciences Department of Ecotoxicology, Analysis Section (see Verification of Test Concentrations).
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Preliminary range finding tests were conducted using test concentrations of 0.1 to 1000 mg/I, under similar exposure conditions to those subsequently employed in the definitive test. The results of these preliminary range finding tests indicated the test substance was of low toxicity to Daphnia at these concentrations
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Source: Institute National de Recherche Chimique Applique (IRChA), France
Stock cultures of Daphnia magna were maintained in glass vessels containing approximately 800 ml of Elendt M4 culture medium with a 16 hour light: 8 hour dark photoperiod at 20 ± 1°C. Cultures were fed daily with a suspension of the unicellular green alga, Chlorella vulgaris. Culture conditions ensured that cultures reproduce by parthenogenesis.
The day before the start of the study, all juvenile Daphnia were removed from the laboratory cultures. The following morning, juveniles produced by the gravid (egg-bearing) adult Daphnia were removed from the culture vessels and held in a separate holding vessel; these animals, which were less than 24 hours old, were used in the test
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- without renewal of test media.
- Post exposure observation period:
- The temperature in each vessel was measured daily and the pH and dissolved oxygen levels recorded at the start and at the end of the study
Test conditions
- Hardness:
- No Data
- Test temperature:
- 20 ± 1 °C,
- pH:
- Maintained between 7.28 and 7.68
- Dissolved oxygen:
- Between 8.33 and 8.45 mg/l
- Salinity:
- No Data
- Nominal and measured concentrations:
- Nominal test concentrations: 1.0, 2.2, 4.6, 10, 22, 46 and 100 mg/I
Mean measured test concentrations: 1.02, 2.25, 4.75, 10.0, 21.5, 44.5 and 93.7 mg/I
- Details on test conditions:
- Seven duplicate concentrations were prepared with one untreated control. The test vessels were 250 ml capacity glass jars.
Ten first instar Daphnia were placed without conscious bias into glass jars, each containing 200 ml of prepared test medium or diluent medium only to give a loading of 20 ml test solution per organism. The jars were loosely covered to minimise evaporative losses. - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Measured concentrations ranged from 101 to 103% of nominal at 0 hours and 86.4 to 104% of nominal at 48 hours
Highest test concentration resulting in 0% immobilisation: 100 mg/I*
Lowest test concentration resulting in 100% immobilisation: > 100 mg/I
- Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- If appropriate, EC10 values were calculated using a logistic model (Berkson, 1944) for which 95% confidence limits were estimated by the likelihood ratio method (Williams, 1986).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 h EC50 (immobilisation value for UK-143,108 with Daphnia magna was determined to be
>100 mg/I, the highest concentration tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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