Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Emergency measure - Inhalation: Remove patient to fresh air. If respiratory symptoms appear,
seek medical attention. In all cases, remove contaminated
clothing and wash before re-use
Emergency measure - Eyes: Immediately flush with plenty of water, seek medical
attention
Emergency measure - Skin: Wash with soap and water
Emergency measure - Ingestion: Seek medical attention (A physician may wish to advise the
use of a gastric lavage. However, the substance is not
corrosive)

Fire-fighting measures

Recommended extinguishing agent: Combustion products may contain carbon, nitrogen and sulphur
oxides together with some ammonia and hydrogen cyanide gas.
A self-contained breathing apparatus should be used.
Suitable extinguishing agents are dry powder, water, carbon
doxide, foam or Halon

Product determined by test: Y

Accidental release measures

Handling and storage

Handling: Avoid contact with skin and eyes, ingestion and inhalation
of dust. Wear suitable protective glasses and rubber gloves
and handle under local exhaust ventilation. A cup type mask
(BS 6016) filtering to 5 micron is recommended when little
exposure is expected. If heavier exposure is anticipated, a
half-face mask with Class P2 filter conforming to DIN 3181
is recommended. In extreme cases of dust inhalation, the
symptoms are as for a cold and last a few days

Storage: Store at ambient temperature in tightly closed polythene
bags in fibre drums. Protect from light as much as possible

Transport information

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Marine transport (IMDG)

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Air transport ICAO/IATA

Remarks
Transport: Transport in tightly closed polythene bags inside fibre
drums
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Exposure controls / personal protection

Stability and reactivity

Danger other than fire: None reported

Chemical reaction with water: Limited solubility in water, no reaction.

Disposal considerations

Industry - Possibility of recovery/recycling: Recovery of material is not possible. All the substance is
converted during use to a pharmaceutical active ingredient

Industry - Possibility of neutralisation: Neutralisation would not be necessary.

Industry - Possibility of destruction: controlled discharge: Not recommended

Industry - Possibility of destruction - incineration: Recommended. Waste gas treatment to remove nitrogen and
sulphur oxides, ammonia and hydrogen cyanide gas should be
used

Industry - Possibility of destruction - water purification: Traces of the substance may be present in mother liquors and
these should not provide any undue problems for a waste
water treatment plant. However the substance itself, which
is not readily biodegradable, should not be discharged to
the aqueous environment in bulk.

Public at large - Possibility of recovery/recycling: The substance will not enter the public domain