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Diss Factsheets
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EC number: 612-366-4 | CAS number: 6172-80-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Body weight at start of study: males 209 g (minimum 204 g, maximum 212 g), females 167 g (minimum 141 g, maximum 178 g)
Age at start of study: males approx. 7 weeks, females approx. 8 weeks
in fully air-conditioned rooms in Makrolon cages (Type 4) on soft wood granulate in groups of 5 animals
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5 male / 5 female
- Control animals:
- no
- Details on study design:
- The prepared test substance was administered by gavage to fasted animals at the stated dosage level. The observation period following treatment lasted 15 days. A record was kept of the times at which signs of intoxication emerged and of the times of death. During this time the animals were weighed weekly. The animals found dead during the study were dissected and autopsied. At the end of the observation period the surviving animals were killed by carbon dioxide asphyxiation, dissected and also examined for macroscopically visible changes.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- During the observation period, no mortality occurred among the females after treatment with 2000 mg/kg body weight. One male died during the 2nd night after treatment.
Based on the results of the present study, the median lethal dose (LD50) for the male and female Wistar rat is with certainty greater than 2000 mg/kg body weight. - Clinical signs:
- The clinical signs of intoxication were rather the same for males and females, but more pronounced in the females. They were marked only on the day of treatment. The clinical signs such as contracted flanks, squatting position, irregular respiration, decreased spontaneous activity, ataxic or stilted gait and piloerection were observed in most animals. The other clinical signs (uncoordinated gait, crawling locomotion, prone position, poor general condition, reduced paw-pinch reflex and placing reflex, no cornea! reflex, stupor, narrowed palpebral fissures, dilated (mydriasis) or contracted (miosis) pupils, panting and increased sound production) occurred to a smaller extent.
- Body weight:
- There were no impairments of body weight gains.
- Gross pathology:
- Macroscopic examination of the male found dead during the study revealed the following abnormalities:
- stomach filled with gas
- lungs discoloured orange.
The remaining animals killed at the end of the observation period were free of macroscopically visible changes.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the mortality rate obtained in this study, the median lethal dose (LD50) for the male and female Wistar rat is with certainty greater than 2000 mg/kg body weight.
According to the criteria defined in the Directive 83/467/EEC butyl methylphosphinate is not subject to labelling requirements.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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