Registration Dossier
Registration Dossier
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EC number: 800-353-8 | CAS number: 1379524-06-7
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic ecotoxicity tests of Amides, C18-unsatd., N-[3-(dimethylamine)propyl] on fish, daphnia and algae have been performed in natural river water. This approach is considered to be conservative but more environmentally realistic than the standard method. Indeed, the substance has a strong tendency to adsorb to negatively charged surfaces (suspended matter, algae, test vessels or organic material). Ecotoxicity tests performed in river water using the bulk approach reduce the bioavailability of the test substance as it occurs in the environment with such substances.
Toxicity to fish:
The study from Kean, 2012 (OECD 203) has a Klimisch rating of 1 and is identified as the key study.
The 96-hour LC50 to Danio rerio under semi-static conditions was 0.94 mg/L.
Therefore, the substance is considered as very toxic to fish.
Toxicity to invertebrates:
An acute toxicity test is available but was identified with a Klimish rating of 3 because the test concentrations were not checked during the test.Nevertheless, a long-term aquatic toxicity study on Daphnia magna (OECD 211) performed with a bulk approach is available (Kean, 2010). The 28d-EC10 based on reproduction
under semi-static conditions was 0.07 mg/L.
Toxicity to aquatic algae:
Toxicity to green algae was evaluated in the study from Kean (2013) identified as the key study with a Klimish rating of 1.
This study was carried out in general accordance with OECD Guideline 201 using some specific modifications (natural surface water supplemented with nutrients and NaHCO3). The bulk approach was applied to the test methodology allowing the use of total aquatic concentrations for calculation of endpoints. The 72 hour ErC10 was calculated as 0.32 mg/L and the ErC50 > 0.96 mg/L (extrapolated value = 1.17 mg/L), expressed as measured initial values. Thus the substance is considered as toxic to algae.
Toxicity to microorganisms:
The toxicity to activated sludge was determined in accordance with OECD 209 in a study from Geerts (2010) identified with a Klimish rating of 1 and as the key study. The EC50 for activated sludge after 3 hours contact time is 192 mg/L.
Therefore, the substance is considered not harmful to activated sludge.
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