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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2000-04-06
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Corrositex TM is a quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: n.a.
Strain:
other: n.a.
Details on test animals and environmental conditions:
Not indicated; in vitro test;

Test system

Type of coverage:
other: n.a.
Preparation of test site:
other: n.a.
Vehicle:
other: n.a.
Controls:
no
Amount / concentration applied:
not indicated
Duration of treatment / exposure:
not indicated
Observation period:
not indicated
Number of animals:
not indicated
Details on study design:
The international Corrositex assay kit is an in vitro method for determining the corrosive potential of chemical substances. The results of this assay were used to determine the United Nations Transport Regulations Packaging Group. For detailed test procedure see Sect. "Any other information on materials and methods incl. tables"

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
mean of breakthrough time (min) of 4 replicates
Value:
17.2
Other effects / acceptance of results:
The results of the categorization screen indicated that the test article, Lithium diisopropylamide, fell into category 1. For further Information, see Sect. "Remarks on results incl. tables and figures"

Any other information on results incl. tables

One run has been performed:

Sample Nr.

1

2

3

4

Detection Time hr:min:sec

00:17:37

00:17:46

00:20:00

00:18.35

Start Time

00:00:00

00:01:01

00:01:45

00.02:25

CORROSITEX Time

00:17.37

00:16:45

00:18:15

00:16:10

Convert to Minutes

17.62

 16.75

18.25

16.17

Mean of 4 Replicates

17.20

According to the results of the Corrositex TM Assay, the test article, Lithium diisopropylamide, has to be classified as corrosive and allocated to packing group II according to the UN Dangerous Goods Transport Regulations

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Lithium diisopropylamide was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations. Lithium diisopropylamide was found to be corrosive and assigned to packing group II. Lithium diisopropylamide has to be classified as corrosive Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and Corrosive R34 according to Directive 67/548/EEC.
Executive summary:

In accordance with column 2 of REACH Regulation 1907/2006/EC Annex VII section 8.1 in-vitro studies for skin corrosion and skin irritation do not need to be conducted if the available information indicates that the criteria are met for classification as corrosive to the skin or the substance is flammable in air at room temperature. Lithium diisopropylamide is pyrophoric and would react violently upon contact with water or air humidity, releasing corrosive lithium hydroxide and lithium diisopropylamine, and likely starting to burn.

Lithium diisopropylamide was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations.

Lithium diisopropylamide was found to be corrosive and assigned to packing group II.

Based on this data and as lithium diisopropylamide reacts violently with water / air humidity to form lithium hydroxide, this substance is also found to be

- corrosive: Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and

- corrosive (R34) according to Directive 67/548/EEC.