Registration Dossier
Registration Dossier
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EC number: 221-882-5 | CAS number: 3268-49-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.34
- Temp.:
- 20 °C
- pH:
- >= 7.4 - <= 7.8
- Conclusions:
- The n-octanol/water partition coefficient of the test substance was determined to be 0.34 at 20 °C and pH 7.4 -7.8. (OECD 107, shake flask method)
Reference
The n-octanol/water partition coefficient of tes substance was investigated in a study conducted according to OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method). Three tests (water/n-octanol: 50/50; 70/20 and 70/10 (v/v; tests conducted in duplicate each) containing initially 141 mg test substance/L water were performed and the log Kows determined. The log Kow was found to be 0.34 +/- 0.07 at 20°C and pH 7.4 -7.8.
Details:
| test | volume water [mL] | volume n-octanol | initial concentration in water [mg/L] | final concentration in water phase [mg/L] | Kow | logKow |
| 1 | 50 | 50 | 141.5 | 48.8 | 1.90 | 0.28 |
| 2 | 50 | 50 | 141.5 | 49.7 | 1.85 | 0.27 |
| 3 | 70 | 20 | 141.5 | 87.7 | 2.15 | 0.33 |
| 4 | 70 | 20 | 141.5 | 85.4 | 2.3 | 0.36 |
| 5 | 70 | 10 | 141.5 | 104.7 | 2.46 | 0.39 |
| 6 | 70 | 10 | 141.5 | 101.8 | 2.73 | 0.44 |
Description of key information
0.34 at 20 °C and pH 7.4-7.8 (OECD 107, flask method)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.34
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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