Registration Dossier
Registration Dossier
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EC number: 485-260-7 | CAS number: 927395-20-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at GLP-accredited facility to current guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 30 °C
- pH:
- 6.72
- Details on results:
- The retention time of the test material (30.361, 30.231 minutes) was slightly longer than that of the most retained reference substance (DDT, 27.451 minutes). The log10Pow for DDT is 6.50. The calibration curve was linear over the range of reference chemicals, with a correlation coefficient of 0.994.
Any other information on results incl. tables
Further investigative work was conducted in which a sample of test material contained water to encourage hydrolysis. There was a considerable reduction in peak size compared to a similar concentration of sample in dried acetonitrile. This indicated that the peak (at ~30.4 minutes) in the chromatograph was the undegraded material.
Applicant's summary and conclusion
- Conclusions:
- The log10Pow for the test material is >6.50.
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