Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Conducted at GLP-accredited facility to current guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
485-260-7
EC Name:
-
Cas Number:
927395-20-8
Molecular formula:
C12 H30 O2 S Si2
IUPAC Name:
485-260-7

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
30 °C
pH:
6.72
Details on results:
The retention time of the test material (30.361, 30.231 minutes) was slightly longer than that of the most retained reference substance (DDT, 27.451 minutes). The log10Pow for DDT is 6.50. The calibration curve was linear over the range of reference chemicals, with a correlation coefficient of 0.994.

Any other information on results incl. tables

Further investigative work was conducted in which a sample of test material contained water to encourage hydrolysis. There was a considerable reduction in peak size compared to a similar concentration of sample in dried acetonitrile. This indicated that the peak (at ~30.4 minutes) in the chromatograph was the undegraded material.

Applicant's summary and conclusion

Conclusions:
The log10Pow for the test material is >6.50.