Registration Dossier
Registration Dossier
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EC number: 201-758-7 | CAS number: 87-62-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity and Skin Corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions
- Author:
- Vernot EH et al.
- Year:
- 1 977
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 42, 417-423
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral dose toxicity was determined by the method of Smyth et al . (1962).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-xylidine
- EC Number:
- 201-758-7
- EC Name:
- 2,6-xylidine
- Cas Number:
- 87-62-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- 2,6-dimethylaniline
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,6-dimethylaniline
- no further data
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300 g
- Diet Purina Formulab Chow 5008 ad libitum
- Water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- no data
- Statistics:
- LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947 ; Weil, 1952).
When fractional mortality was not noted, the LD50 value was listed without a confidence interval.
Occasionally enough data were obtained to use the probit method (Finney, 1971) for calculation.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 230 mg/kg bw
- 95% CL:
- >= 890 - <= 1 700
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Applicant's summary and conclusion
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