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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicity and Skin Corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions
Author:
Vernot EH et al.
Year:
1977
Bibliographic source:
Toxicol. Appl. Pharmacol. 42, 417-423

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity was determined by the method of Smyth et al . (1962).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-xylidine
EC Number:
201-758-7
EC Name:
2,6-xylidine
Cas Number:
87-62-7
Molecular formula:
C8H11N
IUPAC Name:
2,6-dimethylaniline
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2,6-dimethylaniline
- no further data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200-300 g
- Diet Purina Formulab Chow 5008 ad libitum
- Water ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
no
Details on study design:
no data
Statistics:
LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947 ; Weil, 1952).
When fractional mortality was not noted, the LD50 value was listed without a confidence interval.
Occasionally enough data were obtained to use the probit method (Finney, 1971) for calculation.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 230 mg/kg bw
95% CL:
>= 890 - <= 1 700
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data

Applicant's summary and conclusion