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Diss Factsheets
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EC number: 238-778-0 | CAS number: 14726-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data on acute toxicity of zinc bis(dibenzyldithiocarbamate) (ZBEC) were available for assessment. However, based on the data from the structural analogue zinc bis(dibutyldithiocarbamate) (ZDBC), the acute toxicity of zinc bis(dibenzyldithiocarbamate) via oral and dermal routes of exposure is considered to be low, with LD50 > 2000 mg/kg bw/day. No data on inhalation route of exposure are available; however, the performance of a study is not warranted in accordance with Column 2 of REACH Annex X, as the data on two other routes of exposure are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see for more information the read-across justification in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see for more information the read-across justification in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
No data on acute toxicity of zinc bis(dibenzyldithiocarbamate) (ZBEC) were available for the assessment. However, Article 13 of the REACH legislation states that, in case no appropriate animal studies are available for assessment, information should be generated whenever possible by means other than vertebrate animal tests, i.e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across.
Several acute oral toxicity studies with a structural analogue zinc bis(dibutyldithiocarbamate) (ZDBC) were available for assessment, all reporting LD50 values well above 2000 mg/kg bw. Out of these studies, the most recent one (Monsanto Company, 1982), performed under GLP, was chosen as a key study. Five Sprague-Dawley rats of each sex were administered a single oral dose of 5000 mg/kg bw of the test substance as a 434 mg/ml suspension in corn oil. No mortalities occurred and no abnormal findings were noted at necropsy. Diarrhea occurred in three males and five female rats on the day of dosing, but this effect was probably induced by the corn oil used as the dosing vehicle.
Two acute dermal toxicity studies with rabbits using the same test substance were available for assessment, one with very limited reporting. Respectively, the other one, more recent GLP-compliant study (Monsanto, 1982) was chosen as a key study. The test material moistured with physiological saline was administered to abraded skin of a dorsal surface of five New Zealand White rabbits of each sex in the amount of 2000 mg/kg bw under occlusive conditions. After 24 hours the patch was removed, the excessive test material wiped off, and the animals were observed for 14 days and necropsied afterwards. There were no mortalities. Erytherna was observed in the exposed area of three male animals and one female rabbit on the first day after exposure. No other clinical abnormalities were noted. At necropsy, pale renal coloration was observed in one male animal, but this was not considered to be related to exposure to the test material. No abnormalities were observed in the remaining nine rabbits.
Overall, based on the data from the structural analogue zinc bis(dibutyldithiocarbamate) (ZDBC), acute toxicity of zinc bis(dibenzyldithiocarbamate) (ZBEC) is considered to be low as well, with LD50 values for dermal and oral toxicity in rats above the cut-off limit of 2000 mg/kg bw. No data on inhalatory route of exposure were available for assessment. However, the performance of the study is not warranted in accordance with Column 2 of REACH Annex VIII, as data on acute toxicity by other two routes of exposure are available.
Justification for classification or non-classification
Based on the data from the structural analogue zinc bis(dibutyldithiocarbamate) (ZDBC), for which LD50 values in rats of > 5000 mg/kg bw and > 2000 mg/kg bw were reported for acute oral and acute dermal toxicity, respectively, classification of zinc bis(dibenzyldithiocarbamate) (ZBEC) for acute toxicity is not warranted in accordance with Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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