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EC number: 237-158-7 | CAS number: 13674-84-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2-chloro-1-methylethyl) phosphate
- EC Number:
- 237-158-7
- EC Name:
- Tris(2-chloro-1-methylethyl) phosphate
- Cas Number:
- 13674-84-5
- Molecular formula:
- C9H18Cl3O4P
- IUPAC Name:
- tris(2-chloro-1-methylethyl) phosphate
- Details on test material:
- Name of test material : Antiblaze 80
There are differences in the isomer content from each supplier,but these are not important given that the properties of the isomers are expected to be very similar.
Purity
A typical purity(total of the four isomers)is>97.9%.All testing described in this report is for the commercial product.
Impurities
The impurity profile of the commercial product TCPP is specific to individual manufacturers. It is not likely that the impurities will have had particular influence on any of the results obtained.
Additives
No additives are used.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 male and 3 female
- Control animals:
- not specified
- Details on study design:
- The test article was administered dermally to 3 male and 3 female New Zealand White rabbits for 24 hours. The application sites on 2 males and 1 female were abraded through the epidermis, while the applications sites on the remaining animals were left intact. Mortality and clinical signs were recorded for 14 days post-treatment. The application sites were assessed for irritancy at 24 and 72 hours post-treatment.
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No animals died (0/6. deaths).
- Clinical signs:
- All rabbits were clinically normal by Day 2 post-treatment. Transient clinical signs of decreased activity and/or decreased food intake were noted in 4/6 animals.
- Body weight:
- no data
- Gross pathology:
- No necropsy details were provided.
- Other findings:
- no data
Any other information on results incl. tables
No animals died (0/6. deaths). All rabbits were clinically normal by Day 2 post-treatment. Transient clinical signs of decreased activity and/or decreased food intake were noted in 4/6 animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The substance shows very low dermal toxicity.
- Executive summary:
Nothing to add in this field.
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