Registration Dossier

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of test material : Antiblaze 80
There are differences in the isomer content from each supplier,but these are not important given that the properties of the isomers are expected to be very similar.
Purity
A typical purity(total of the four isomers)is>97.9%.All testing described in this report is for the commercial product.
Impurities
The impurity profile of the commercial product TCPP is specific to individual manufacturers. It is not likely that the impurities will have had particular influence on any of the results obtained.
Additives
No additives are used.

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
24h
Doses:
2000 mg/kg
No. of animals per sex per dose:
3 male and 3 female
Control animals:
not specified
Details on study design:
The test article was administered dermally to 3 male and 3 female New Zealand White rabbits for 24 hours. The application sites on 2 males and 1 female were abraded through the epidermis, while the applications sites on the remaining animals were left intact. Mortality and clinical signs were recorded for 14 days post-treatment. The application sites were assessed for irritancy at 24 and 72 hours post-treatment.
Statistics:
no data

Results and discussion

Preliminary study:
no
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No animals died (0/6. deaths).
Clinical signs:
All rabbits were clinically normal by Day 2 post-treatment. Transient clinical signs of decreased activity and/or decreased food intake were noted in 4/6 animals.
Body weight:
no data
Gross pathology:
No necropsy details were provided.
Other findings:
no data

Any other information on results incl. tables

No animals died (0/6. deaths). All rabbits were clinically normal by Day 2 post-treatment. Transient clinical signs of decreased activity and/or decreased food intake were noted in 4/6 animals.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The substance shows very low dermal toxicity.
Executive summary:

Nothing to add in this field.