Registration Dossier

Administrative data

Endpoint:
neurotoxicity: acute oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: USA EPA proposed guideline for acute delayed neurotoxicity FR43(163):37362-37363,1978
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
hen
Strain:
other: white leghorn hen
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Vehicle:
corn oil
Duration of treatment / exposure:
No data.
Frequency of treatment:
Two doses (10ml/kg each) were administered orally to hens 21 days apart.
Doses / concentrations
Remarks:
Doses / Concentrations:
10ml/kg
Basis:
no data
No. of animals per sex per dose:
18 animals per dose
Control animals:
yes
Details on study design:
The study has positive and negative control
positive control: TOCP
negative control: corn oil

Results and discussion

Results of examinations

Details on results:
No inhibit either plasma and cholinesterase or brain neurotoxic esterase 24 hours after dosing.
No motor impairment observed to compare with that seen in TOCP group.

Applicant's summary and conclusion

Conclusions:
No evidence of delayed neurotoxicity was noted.