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EC number: 204-800-2 | CAS number: 126-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EG-Richtlinie 84/449 (Amtsblatt der Europäischen Gemeinschaften 27, 1984, L 251, 96)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: 9 (males) to 14 (females) weeks
- Weight at study initiation: 165 g for males and 163 g for females
- Fasting period before study: 16 h
- Housing: 5 animals per cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +- 2
- Humidity (%): 50 +- 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1986-14-01 To: 1986-02-24
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1.3; 1.5; 1.8; 2,.0; 3.1 mL/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
- Details on study design:
- body weight was determined before application, one week later and at the end of the 14-day observation period
- Statistics:
- after Rosiello et al., J. Tox. Environ. Health 3, 797, 1977
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 1 552 mg/kg bw
- Mortality:
- 1,5 ml/kg bw: 2 male/ 2 female
1,8 ml/kg bw: 3 male/ 4 female
2,0 ml/kg bw: 4 male/ 4 female
3,1 ml/kg bw: 5 male/ 5 female - Clinical signs:
- other: Clinical signs were observed in dose groups: 1,5; 1,8; 2,0; 3,1 ml/kg bw.
- Gross pathology:
- No findings in dose group 1,3 ml/kg.
In dose group 1,5 ml/kg 4 rats (2 male/2 female) showed effects on gastric mucosa.
In the 1,8 ml/kg dose group 3 male animals showed effects on gastric mucosa and 4 female animals had effects on gastric mucosa, inflated intestine and reddened stomach.
In the 2,0 ml/kg dose group 4 male and 4 female animals showed effects on gastric mucosa, inflated intestines and a reddened lung. In the dose group of 3,1 ml/kg all animals (5male/ 5 female) showed effects on gastric mucosa, inflated intestines and a reddened lung.
Any other information on results incl. tables
After a single oral dose of 1,5 up to 3,1 ml/kg bw following symptoms could be observed in the test animals:
Diminished general condition; narcosis, bloody eye margins, face down position or lateral position, ruffled fur.
Applicant's summary and conclusion
- Executive summary:
Tributyl phosphate was tested in a single dose experiment in male and female Wistar rats.
The doses tested were: 1,3; 1,5; 1,8; 2,0; 3,1 ml/kg bw.
Signs of intoxication were: diminuated general condition; narcose, bloody eye margins, face down position or lateral position, ruffled fur.
The LD50 was: 1,6 ml/kg bw for male and female rats.
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