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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EG-Richtlinie 84/449 (Amtsblatt der Europäischen Gemeinschaften 27, 1984, L 251, 96)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1,3; 1,5; 1,8; 2,0; 3,1 ml/kg bw.
No. of animals per sex per dose:
5/sex/dose
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
1 552 mg/kg bw
Mortality:
1,5 ml/kg bw: 2 male/ 2 female
1,8 ml/kg bw: 3 male/ 4 female
2,0 ml/kg bw: 4 male/ 4 female
3,1 ml/kg bw: 5 male/ 5 female
Clinical signs:
Clinical signs were observed in dose groups: 1,5; 1,8; 2,0; 3,1 ml/kg bw.
Body weight:
The average animal weight at the beginning of the experiment was: 165 g (male rats) and 163 (female rats).
Body weights during experiment: no reduction of weight in surviving animals.
Gross pathology:
No findings in dose group 1,3 ml/kg.
In dose group 1,5 ml/kg 4 rats (2 male/2 female) showed effects on gastric mucosa.
In the 1,8 ml/kg dose group 3 male animals showed effects on gastric mucosa and 4 female animals had effects on gastric mucosa, inflated intestine and reddened stomach.
In the 2,0 ml/kg dose group 4 male and 4 female animals showed effects on gastric mucosa, inflated intestines and a reddened lung. In the dose group of 3,1 ml/kg all animals (5male/ 5 female) showed effects on gastric mucosa, inflated intestines and a reddened lung.

Any other information on results incl. tables

After a single oral dose of 1,5 up to 3,1 ml/kg bw following symptoms could be observed in the test animals:

Diminuated general condition; narcose, bloody eye margins, face down position or lateral position, ruffled fur.

Applicant's summary and conclusion

Executive summary:

Tributyl phosphate was tested in a single dose experiment in male and female Wistar rats.

The doses tested were: 1,3; 1,5; 1,8; 2,0; 3,1 ml/kg bw.

Signs of intoxication were: diminuated general condition; narcose, bloody eye margins, face down position or lateral position, ruffled fur.

The LD50 was: 1,6 ml/kg bw for male and female rats.