Registration Dossier
Registration Dossier
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EC number: 228-845-2 | CAS number: 6362-79-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although conducted prior to current protocol or GLP requirements, the study conformed to recognized protocols current at the time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- Performed prior to current protocol or GLP requirements but by a method acceptable at the time.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sodium hydrogen-5-sulphoisophthalate
- EC Number:
- 228-845-2
- EC Name:
- Sodium hydrogen-5-sulphoisophthalate
- Cas Number:
- 6362-79-4
- Molecular formula:
- C8H6O7S.Na
- IUPAC Name:
- Sodium 3,5-dicarboxybenzenesulfonate
- Reference substance name:
- 288-845-2
- IUPAC Name:
- 288-845-2
- Reference substance name:
- Sodium-3,5-dicarboxybenzenesulfonate
- IUPAC Name:
- Sodium-3,5-dicarboxybenzenesulfonate
- Reference substance name:
- 5-(Sodiosulfo)isophthalic acid
- IUPAC Name:
- 5-(Sodiosulfo)isophthalic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of test material: 5-(sodiosulfo)isophthalic acid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Intraperitoneal injection of a 10% solution in water.
- Doses:
- 200 to 3200 mg/kg bwt
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 800 mg/kg bw
- Mortality:
- Mortality occurred from 1 hour to 7 days following exposure.
- Clinical signs:
- In affected animals, clinical signs included normal to very weak; prostration; labored respiration; tremors; and rough coat.
- Body weight:
- After a 2-week post-treatment observation period, weight gains of 5+g were noted.
Applicant's summary and conclusion
- Conclusions:
- The test material was slightly toxic to rats following intraperitoneal administration.
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