Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Although this pre-dates international guidelines for acute oral toxicity studies and GLP, in accordance with REACH Annex XI, Section 1.1.2, the study was conducted under sound scientific principles of acute toxicity studies. The study is therefore considered adequate for contributing evidence towards this endpoint in a weight of evidence approach.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption
- Author:
- T. Czajkowska
- Year:
- 1 972
- Bibliographic source:
- Czajkowska, T., Stetkiewicz, J. (1972) Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption. Medycyna Pracy, 23: 363-371.
Materials and methods
- Principles of method if other than guideline:
- Rats were given single doses of phenylglycidyl ether by oral gavage and the observation period was 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-epoxypropyl phenyl ether
- EC Number:
- 204-557-2
- EC Name:
- 2,3-epoxypropyl phenyl ether
- Cas Number:
- 122-60-1
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 2-(phenoxymethyl)oxirane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 600 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- Histopathological examination of the livers in the animals that died revealed nodule formation and necrosis of the liver parenchyma.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of phenylglycidyl ether to Wistar rats was estimated as 2600 mg/kg.
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