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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute toxicity testing by any route (oral, inhalation, and dermal) demonstrate no evidence of toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
3 730 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
5 000 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

A series of acute exposure studies with DBM were conducted either according or similar to the OECD Guidelines. The acute oral LD50 values were reported > 3730 mg/kg bw (key study) and 20,000 mg/kg bw in rats and 14,000 mg/kg bw in mice. A dermal LD50 value greater than 2000 mg/kg has also been reported in rats (RL1). A reliable acute inhalation (aerosol) study has also been performed in Sprague-Dawley male and female rats (RL1). Test animals were exposed for 4 hour (nose-only) at 5000 mg/m3. No animals died and no signs of toxicity were noted during or after axposure. The LC50 was determined to be greater than 5000 mg/m3 (in aerosol).

Justification for classification or non-classification

According to criteria in Regulation (EC) No.1272/2008 the substance does not have to be classified for acute oral, inhalation or dermal toxicity, based on the observed LD50 values (acute oral toxicity: LD50 between >= 3730 mg/kg in rats and 20,000 mg/kg bw in mice; acute inhalation toxicity > 5000 mg/m3 (in aerosol); acute dermal toxicity: LD50 > 2000 mg/kg bw in rats).