Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of mercaptobenzothiazole
- Author:
- Randall, D., J.; et al.
- Year:
- 1 990
- Bibliographic source:
- Journal of American College of Toxicology, part B, vol.1, 62
Materials and methods
- Principles of method if other than guideline:
- other: acute dermal toxicity study
- GLP compliance:
- no
- Test type:
- other: acute dermal toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- mercaptobenzothiazole (MBT), purity: 97.4 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 h
- Doses:
- 5010, 7940 mg/kg bw
- No. of animals per sex per dose:
- 1 to 2
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Remarks on result:
- other: Clinical signs: reduced appetite and activity for 1 to 2 days
Any other information on results incl. tables
No mortality occurred. The dermal LD50 for MBT was greater than 7940 mg/kg bw. Clinical signs included reduced appetite and activity for 1 to 2 days. Viscera of animals appeared normal at sacrifice.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
