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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline Study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
gas saturation method
Temp.:
25 °C
Vapour pressure:
0 Pa

Results of the gas saturation experiments at 50°C

The experiments at 50°C were performed using three flow rates (2.00 L/min, 1.00 L/min and 0.20 L/min) during approximately 12 (experiment no.1) or 7 days (experiment no.3). Flow rate, pressure and temperature were checked and recorded 5 (no. 1) or 3 (no. 3) times in that period. The collected vapor was desorbed from the traps with acetonitrile. The amount of test substance in the eluent was determined by GC method.

The results of the measurements are summarized in the following table:

The results of the saturation experiments with the test substance at 50°C

Channel number

Temperature (°C)

Flow (L/min)

Time (min)

PS(Pa)

Wg(mg)

P (Pa)

1

46.0

2.015

9825

2.16 x 105

34.917

2.01 x 10-5

2

-

-

-

-

-

-

3

46.6

0.9968

17085

1.14 x 105

49.081

1.73 x 10-5

* At flow rate of 1.00 L/min there was a leakage in the test equipment. Therefore, only the results of experiment 1 and 3 were used for the calculation.

Results of the gas saturation experiments at 40°C

The experiments at 40°C were performed using three flow rates (2.00 L/min, 1.00 L/min and 0.20 L/min) during approximately 13 days. Flow rate, pressure and temperature were checked and recorded 9 times in that period. The collected vapor was desorbed from the traps with acetonitrile. The amount of test substance in the eluent was determined by GC method.

The results of the measurements are summarized in the following table:

The results of the saturation experiments with the test substance at 40°C

Channel number

Temperature (°C)

Flow (L/min)

Time (min)

PS(Pa)

Wg(mg)

P (Pa)

1

-

-

-

-

-

-

2

-

-

-

-

-

-

3

39.2

0.9968

18345

1.11 x 105

17.848

5.71 x 10-6

* At flow rate of 2.00 and 1.00 L/min there was a leakage in the test equipment. Therefore, only the results of experiment 3 was used for the calculation.

Results of the gas saturation experiments at 30°C

The experiments at 30°C were performed using three flow rates (2.00 L/min, 1.00 L/min and 0.20 L/min) during approximately 7 days. Flow rate, pressure and temperature were checked and recorded 4 times in that period. The collected vapor was desorbed from the traps with acetonitrile. The amount of test substance in the eluent was determined by GC method.

The results of the measurements are summarized in the following table:

The results of the saturation experiments with the test substance at 30°C

Channel number

Temperature (°C)

Flow (L/min)

Time (min)

PS(Pa)

Wg(mg)

P (Pa)

1

29.4

2.015

9910

1.95 x 105

9.778

5.04 x 10-6

2

-

-

-

-

-

-

3

29.4

0.9968

9910

1.08 x 105

7.029

4.04 x 10-6

* At flow rate of 1.00 L/min there was a leakage in the test equipment. Therefore, only the results of experiments 1 and 3 were used for the calculation.

Conclusion of the gas saturation experiments

In a Clausius-Clapeyron plot, the logarithm of the vapor pressure is plotted as a function of the inverse temperature. The vapor pressure of the test substance at 25°C can be estimated by extrapolation using the trendline that describes the vapor pressure as function of T. The vapor pressure at 25°C is calculated to be 2.9 x 10-6 Pa.

Executive summary:

The gas saturation method as outlined in the OECD guideline 104 was used to ascertain the vapor pressure of the test material. The vapor pressure of the test substance at 25°C was estimated by extrapolation using the trendline that described the vapor pressure as function of T. The vapor pressure at 25°C is calculated to be 2.9 x 10-6 Pa.

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: EU method and GLP study.
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
other: balance method
Temp.:
25 °C
Vapour pressure:
0 Pa

Vapour pressure at 25 ºC = 6 x 10 -8 Pa

Conclusions:
Vapour pressure at 25 ºC = 6 x 10 -8 Pa
Executive summary:

The vapour pressure was determined according to EU method A.4 (balance method) to be 6 x 10 -8 Pa at 25 ºC

Description of key information

Key study: experimental results: GLP study. The vapour pressure was determined according to EU method A.4 to be 6 x 10 -8 Pa at 25 ºC

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

Key study: experimental results: GLP study. The vapour pressure was determined according to EU method A.4 to be 6 x 10 -8 Pa at 25 ºC