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Melting point / freezing point

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Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline Study under GLP
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
capillary method
Melting / freezing pt.:
156.4 °C

Preliminary Test:

The capillary tube containing the test substance was placed in the oven of the melting point apparatus, which was heated at a heating rate of 1 K/min, starting at 418.2 K (145.0°C).
At a temperature of 428.8 K (155.6°C) the test substance started to melt.

At a temperature of 429.7 K (156.5°C) the test substance was melted completely.

Test 1:

After heating the oven to 423.2 K (150.0°C), the capillary tube containing the test substance was placed in the oven of the melting point apparatus, which was heated at a rate of 0.5 K/min.

At a temperature of 428.6 K (155.4°C) the test substance started to crimp.

At a temperature of 428.8 K (155.6°C) the test substance started to collapse.

At a temperature of 429.0 K (155.8°C) the test substance started to liquefy.

At a temperature of 429.5 K (156.3°C) the test substance was melted completely.

Test 2:

After heating the oven to 423.2 K (150.0°C), the capillary tube containing the test substance was placed in the oven of the melting point apparatus, which was heated at a rate of 0.5 K/min.

At a temperature of 428.8 K (155.6°C) the test substance started to crimp.

At a temperature of 429.0 K (155.8°C) the test substance started to collapse.

At a temperature of 429.2 K (156.0°C) the test substance started to liquefy.

At a temperature of 429.7 K (156.5°C) the test substance was melted completely.

Results

The test substance has a melting temperature of 429.6±0.1 K (156.4±0.1°C).
Conclusions:
The meaured melting temperature of the test substance is 429.6±0.1 K (156.4±0.1°C).
Executive summary:

The melting temperature of the test substance was determined with the capillary method according to the OECD 102 Guideline for testing of chemicals and TNO Standard Operating Procedure Q 213-W-02 ‘Determination of the melting point/melting range’. The test substance (3 mm) was charged in a capillary tube and packed tightly. An Electrothermal IA 9200 melting point apparatus was used. The meaured melting temperature of the test substance is 429.6±0.1 K (156.4±0.1°C).

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Handbook
Principles of method if other than guideline:
No data provided on test method.
GLP compliance:
not specified
Melting / freezing pt.:
154 °C
Conclusions:
Melting point: 154 ºC
Executive summary:

Melting point: 154 ºC

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Handbook
Principles of method if other than guideline:
No data provided on test method.
GLP compliance:
not specified
Melting / freezing pt.:
155 °C
Conclusions:
Melting point: 155 ºC
Executive summary:

Melting point: 155 ºC

Description of key information

The measured melting temperature of the test substance is 429.6±0.1 K (156.4±0.1°C).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
429.6 K

Additional information

The measured melting temperature of the test substance is 429.6±0.1 K (156.4±0.1°C). This is in agreement with handbook data giving melting temperatures between 154-155 ºC