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EC number: 231-710-0 | CAS number: 7695-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted similar to OECD Guideline 402, but not under GLP. Report is well documented, and the design is considered scientifically accepted.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- no
- Remarks:
- but with Quality Assurance Unit Statement
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
- EC Number:
- 231-710-0
- EC Name:
- 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
- Cas Number:
- 7695-91-2
- Molecular formula:
- C31H52O3
- IUPAC Name:
- 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): dl-alpha-tocopheryl-acetate
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino - SPF
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Füllinsdorf
- Weight at study initiation:
Males: 230.40 +/- 7.42 g
Females: 197.67 +/- 6.40 g
- Housing: Individually in metal cages
- Diet: Ad libitum, Nafag 850
- Water: Ad libitum, tap water
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1
- Humidity (%): 55 +/- 10
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- vegetable oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorso-lumbar region
- % coverage: 10% (16 cm²)
- Type of wrap: Gauze and Pergamine paper + occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Luke warm water
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- 1000 and 3000 mg/kg (= pure substance)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: almost once daily
- Necropsy of survivors performed: yes - Statistics:
- Not relevant
Results and discussion
- Preliminary study:
- Not relevant
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Remarks on result:
- other: Maximum dosable concentration was limited by the volume of the substance (maximum volume reached at 3000 mg/kg bw)
- Mortality:
- No mortalities were recorded during the observation period
- Clinical signs:
- other: Treated animals showed only few signs of skin irritation which appeared 24 - 48 hours after dermal exposure. Erythemas were of low grade (maximum l), and only 2 males (3000 mg/kg) and 3 females (1 with 1000 mg/kg and 2 with 3000 mg/kg) showed signs of sli
- Gross pathology:
- No abnormalities
- Other findings:
- Not reported
Any other information on results incl. tables
Not relevant
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is not classified according to EU criteria (67/548/EEG) as the LD50 >3000 mg/kg. Only minor effects on weight and skin have been
observed. - Executive summary:
D, L- alpha-Tocopheryl acetate, which is a derivative of Vitamine E, has been tested in an acute dermal toxicity test (similar to OECD 402, test system: Rat).
A maximum dosis of 3000 mg/kg was applied as the pure substance, which is a viscous oil. A low dosis of 1000 mg/kg was a mixture of the substance with a vegetable oil. This same oil was applied in control groups.
No dermal LD50 could be achieved up to 3000 mg/kg, since no mortality occured.
The test substance causes only slight local erythemas which appear 24 - 48 hours after application. Only few animals showed signs of local abrasion. Female animals are slightly more sensitive to treatment than male animals. Bodyweights were reduced in all groups after the initial 24 h application period. In male groups further weight development was normal. For treated females a slight retardation of weight gain was evident during the first week of the observation period. Final autopsies showed no abnormalities that could be related to treatment.
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