Registration Dossier
Registration Dossier
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EC number: 200-175-5 | CAS number: 53-43-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from peer-reviewed handbook or collection of data
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Water solubility:
- 63.5 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: pH value not reported
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of Prasterone is 63.5 mg/L at 25°C. - Executive summary:
The water solubility of Prasterone is 63.5 mg/L at 25°C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 17.5 mg/L
- Temp.:
- 20 °C
- pH:
- 5.4
- Details on results:
- The insoluble residues of the solubility experiments were examined by X-ray powder diffractometry (XRPD) and compared with the starting material. Different X-ray diffractograms were measured indicating a change of the solid state form during the solubility experiment. The insoluble residues were identified as monohydrate.
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of 3 beta-Hydroxy-5-androsten-17-one is 17.5 +/-0.1 mg/L at 20°C. - Executive summary:
The water solubility of 3 beta-Hydroxy-5-androsten-17-one was determined according to EU Method A.6 (Water Solubility) which is equivalent to OECD Guideline 105. The water solubility of the test item is 17.5 +/-0.1 mg/L at 20°C, pH 5.44.
Referenceopen allclose all
Results of the HPLC analysis for solubility experiments at 20 °C
| Days | Experiment 1 | Experiment 1 | Experiment 2 | Experiment 2 |
| c1 [mg/L] | pH | c2 [mg/L] | pH | |
| 1 | 17.281 | 5.56 | 17.353 | 5.46 |
| 2 | 17.501 | 5.44 | 17.519 | 5.42 |
| 3 | 17.755 | 5.38 | 17.717 | 5.41 |
| 4 | 17.474 | 5.42 | 17.568 | 5.41 |
Averaging the results of 8 samples (2 experiments) the following solubility at 20 °C was calculated with 95 % confidence interval:
S20=17.5 +/- 0.1 mg/L
The pH values of the solutions were averaged (n=8; 2 experiments) to be pH=5.44 +/- 0.05.
Description of key information
The water solubility of 3 beta-Hydroxy-5-androsten-17-one is 17.5 +/-0.1 mg/L at 20°C, pH 5.44.
Key value for chemical safety assessment
- Water solubility:
- 17.5 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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