Registration Dossier
Registration Dossier
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EC number: 240-004-1 | CAS number: 15875-13-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Work pre-dates guidelines and GLPs, Limited documentation, list published in peer-reviewed journal. 24-hour exposure
- Justification for type of information:
- Work pre-dates guidelines and GLPs, Limited documentation, list published in peer-reviewed journal. 24-hour exposure
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- Primary irritation on rabbits was recorded in a 10-grade ordinal series based on the severest reaction that developed on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of the test sample.
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- EC Number:
- 240-004-1
- EC Name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- Cas Number:
- 15875-13-5
- Molecular formula:
- C18H42N6
- IUPAC Name:
- (3-{3,5-bis[3-(dimethylamino)propyl]-1,3,5-triazinan-1-yl}propyl)dimethylamine
- Test material form:
- other: 85% aqueous solution
- Details on test material:
- 85% aqueous solution of N,N-(dimethylaminopropyl)-s-hexahydrotriazine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Amount / concentration applied:
- 0.01 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: Unknown. List entry.
- Time point:
- 24 h
- Score:
- >= 5
- Max. score:
- 5
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Following a 24-hour open exposure the material was irritating but not corrosive. Score of 5 out of 10.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The material is irritating to the skin following a 24-hour open exposure.
- Executive summary:
The material is irritating to the skin following a 24-hour open exposure. Graded a 5 out of 10.
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