Registration Dossier
Registration Dossier
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EC number: 205-526-6 | CAS number: 142-18-7
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature. Original report not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyc
- Author:
- Cosmetic Ingredient Review (CIR)
- Year:
- 2 004
- Bibliographic source:
- Int J Toxicol. 2004;23 Suppl 2:55-94
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 997
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- Inhalation toxicity study in rats (14 one-hour exposures during 3 weeks)
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-dihydroxypropyl laurate
- EC Number:
- 205-526-6
- EC Name:
- 2,3-dihydroxypropyl laurate
- Cas Number:
- 142-18-7
- Molecular formula:
- C15H30O4
- IUPAC Name:
- 2,3-dihydroxypropyl dodecanoate
- Details on test material:
- - Name of test material (as cited in study report): glyceryl monolaurate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: No data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 weeks (14 one-hour exposures)
- Frequency of treatment:
- 1 h/day, (presumably) 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
280 mg/m³
Basis:
nominal conc.
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- NOEC
- Effect level:
- 280 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: as reported
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
In an inhalation study in rats, glyceryl monolaurate gave a no effect level of 280 mg/m³ in 14 one-hour exposures during three weeks.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
