Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

other: JIS K 0102-1986, 71

Principles of method if other than guideline:

conducted in accordance with "Method for Testing the Bioaccumulation of new chemical substances in Fish" (Kanpogyo No .S, Yakuhatsu No . 615, 49-Kikyoku No . 392, MITI/MHW Chemical Substance Control Law, Japan, promulgated July 13, 1974).

GLP compliance:

no

Vehicle:

no

Test organisms (species):

Cyprinus carpio

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

8 wk

Test temperature:

25 °C

Details on test conditions:

TEST SYSTEM
- Renewal rate of test solution (flow rate): 580 L per day
- No. of organisms per vessel: 20

Nominal and measured concentrations:

Nominal test concentration: 0.1 and 0.01 mg/L

Type:

BCF

Value:

47 - 55

Time of plateau:

8 wk

Remarks on result:

other: after 2 weeks

Remarks:

Conc.in environment / dose:0.1

Type:

BCF

Value:

38 - 55

Time of plateau:

8 wk

Remarks on result:

other: after 4 weeks

Remarks:

Conc.in environment / dose:0.1

Type:

BCF

Value:

37 - 42

Time of plateau:

8 wk

Remarks on result:

other: after 6 weeks

Remarks:

Conc.in environment / dose:0.1

Type:

BCF

Value:

23 - 40

Time of plateau:

8 wk

Remarks on result:

other: after 8 weeks

Remarks:

Conc.in environment / dose:0.1

Type:

BCF

Value:

53 - 72

Time of plateau:

8 wk

Remarks on result:

other: after 2 weeks

Remarks:

Conc.in environment / dose:0.01

Type:

BCF

Value:

22 - 32

Time of plateau:

8 wk

Remarks on result:

other: after 4 weeks

Remarks:

Conc.in environment / dose:0.01

Type:

BCF

Value:

31 - 56

Time of plateau:

8 wk

Remarks on result:

other: after 6 weeks

Remarks:

Conc.in environment / dose:0.01

Type:

BCF

Value:

18 - 22

Time of plateau:

8 wk

Remarks on result:

other: after 8 weeks

Remarks:

Conc.in environment / dose:0.01

Actual means of test concentration in test solution (mg/l )

nominal 0.1: 0.0864 (2 wk), 0.0917 (4 wk), 0.0946 (6 wk), 0.0952 (8 wk)

nominal 0.01: 0.00827 (2 wk), 0.00895 (4 wk), 0.00926 (6 wk), 0.00936 (8 wk)

Key value for chemical safety assessment

BCF (aquatic species):

72 dimensionless

Additional information

A bioaccumulation study with Cyprinus carpio has been performed according to the Japanese guideline “Method for Testing the Bioaccumulation of new chemical substances in Fish”. Organisms have been exposed for 8 weeks in a flow-through system to substance concentrations of 0.1 mg/l and 0.01 mg/l. The BCF was 23-55 for the higher concentration (0.1 mg/l) and 18-72 for the lower concentration (0.01 mg/l), respectively. The analytical measurements were performed after 2, 4, 6 and 8 weeks.