Registration Dossier
Registration Dossier
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EC number: 617-345-3 | CAS number: 82543-14-4
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2001-03-09
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- yes
- Remarks:
- UV/Vis absorption spectra were measured in the flow cell of an HPLC diode array at different pH values.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one
- EC Number:
- 617-345-3
- Cas Number:
- 82543-14-4
- Molecular formula:
- C25H36O4
- IUPAC Name:
- 5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one
Constituent 1
Results and discussion
- Dissociating properties:
- no
Applicant's summary and conclusion
- Executive summary:
The chemical structure of ZK 90504 does not show any groups which can be protonated or deprotonated. To estimate the acid/base properties of ZK 90504, the UV/VIS spectra were measured in the pH region 2 -11. No spectral change was observed. Therefore, ZK 90504 can be considered as a neutral molecule in the pH range 2 - 10, which is of relevance for biological systems.
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