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Administrative data

Description of key information

Acute toxicity data indicate a low toxicity: in rats the oral LD50 was ca. 2700 mg/kg bw. Inhalation exposure for 8 hours to vapour saturated with di-tridecamine failed to caused any deaths in rats. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
2 700 mg/kg bw

Additional information

Oral toxicity

In an oral toxicity study, comparable to OECD 401, Gassner rats (10/sex/dose) were administered di-tridecamine at 200, 1600, 2000, 2500, 3200, 6400 mm3/kg (equivalent to ca. 164 to 5236 mg/kg) by single dose (gavage) followed by a 7-day observation period (BASF AG, 1970). Clinical signs included dyspnoea, apathy and diarrhea. Findings at necropsy included sporadically, considerable injection of the gastric vessels. The LD50 was 2700 mg/kg bw.

 

Inhalation toxicity

In a study in which rats were exposed to a saturated di-tridecamine atmosphere (concentration not given) at 20°C, no deaths were observed during a 7-day observation period after 8 hours of exposure, therefore no LC50 value has been determined for this compound (BASF AG, 1970).

 

Dermal toxicity

No reliable acute dermal toxicity data is available. However, in accordance with column 2 of REACH Annex VIII, in addition to the oral route at least one other route shall be provided. According to REACH Annex VIII no further testing on acute toxicity is necessary if the substance is classified as corrosive to the skin.

Justification for classification or non-classification

Based on the results of the acute oral and inhalation toxicity studies, di-tridecamine does not need to be classified according to Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.