Registration Dossier
Registration Dossier
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EC number: 201-928-0 | CAS number: 89-65-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate,Erythorbic Acid, and sodium Erythorbate
- Author:
- F. Alan Andersen
- Year:
- 1 999
- Bibliographic source:
- International Journal of Toxicology
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Rats fed Erythorbic Acid at 1% of the diet for six months. Though no guideline available, the report was reviewed by peers. And this substance was fully used as food additive.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,3-didehydro-D-erythro-hexono-1,4-lactone
- EC Number:
- 201-928-0
- EC Name:
- 2,3-didehydro-D-erythro-hexono-1,4-lactone
- Cas Number:
- 89-65-6
- Molecular formula:
- C6H8O6
- IUPAC Name:
- (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 500 mg/kg diet
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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