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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Final Report on the Safety Assessment of Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate,Erythorbic Acid, and sodium Erythorbate
Author:
F. Alan Andersen
Year:
1999
Bibliographic source:
International Journal of Toxicology

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Rats fed Erythorbic Acid at 1% of the diet for six months. Though no guideline available, the report was reviewed by peers. And this substance was fully used as food additive.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-didehydro-D-erythro-hexono-1,4-lactone
EC Number:
201-928-0
EC Name:
2,3-didehydro-D-erythro-hexono-1,4-lactone
Cas Number:
89-65-6
Molecular formula:
C6H8O6
IUPAC Name:
5-(1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one (non-preferred name)

Test animals

Species:
rat

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 500 mg/kg diet

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion