Registration Dossier

Administrative data

First-aid measures

The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.

Description of first aid measures

General advice :
First Aid responders should pay attention to self-protection and use the recommended protective clothing
Move out of dangerous area.
Take off contaminated clothing and shoes immediately.
Keep warm and in a quiet place.

If inhaled :
Provide fresh air.
If not breathing, give artificial respiration.
Keep the victim calm and in a semi-upright position.
Call a physician immediately.

In case of skin contact :
Wash off immediately with plenty of water for at least 15 minutes.
Call a physician immediately.

In case of eye contact :
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Call a physician immediately.

If swallowed :
Clean mouth with water and drink afterwards plenty of water.
Never give anything by mouth to an unconscious person.
Do NOT induce vomiting.
Call a physician immediately.


Most important symptoms and effects, both acute and delayed

Symptoms :
Drowsiness
Unconsciousness
headache
Tiredness
Dizziness
Irritation
Nausea
Breathing difficulties

Risks :
Risk of serious damage to the lungs (by aspiration).
Lung oedema


Indication of any immediate medical attention and special treatment needed

Treatment :
Treat symptomatically.
For specialist advice physicians should contact the Poisons
Information Service.

Fire-fighting measures

The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.


Extinguishing media

Suitable extinguishing media :
Alcohol-resistant foam
Dry extinguishing media based on NaCl or pulverized limestone.

Unsuitable extinguishing media:
Water
Carbon dioxide (CO2)


Special hazards arising from the substance or mixture

Specific hazards during firefighting:
Vapours may form explosive mixture with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.
Hazardous decomposition products formed under fire conditions.
Carbon monoxide
Carbon dioxide (CO2)


Advice for firefighters

Special protective equipment for firefighters:
Wear full protective clothing and self-contained breathing apparatus.

Further information :
Use water spray to cool unopened containers.
Collect contaminated fire extinguishing water separately. This must not be discharged into drains.
Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations.

Accidental release measures

The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.

Personal precautions, protective equipment and emergency procedures

Personal precautions :
Remove all sources of ignition.
Ensure adequate ventilation.
Wear personal protective equipment.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep people away from and upwind of spill/leak.


Environmental precautions

Environmental precautions:
Do not flush into surface water or sanitary sewer system.
Avoid subsoil penetration.


Methods and materials for containment and cleaning up

Methods for cleaning up :
Never allow contact with water.
Cover spilled material with limestone powder.
Pick up and transfer to properly labelled containers.
Non-sparking tools should be used.
Adequate disposal

Handling and storage

The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.


Precautions for safe handling

Advice on safe handling :
Handle under inert gas.
Never allow water to come into contact with the product.
Use product only in closed system.
Provide sufficient air exchange and/or exhaust in work rooms.
Provide exhaust ventilation close to floor level.
Wear personal protective equipment.
Avoid formation of aerosol.
Handle in accordance with good industrial hygiene and safety practice.
In general, emissions are controlled and prevented by implementing an appropriate management system, including regular informing and training workers.

Advice on protection against fire and explosion:
Vapours may form explosive mixtures with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.
Keep away from sources of ignition - No smoking.
Take precautionary measures against static discharges.
Use explosion-proof equipment.
Uncleaned empty containers can contain product gases, which form explosive mixtures with air.


Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers:
Keep under inert gas.
Keep containers tightly closed in a dry, cool and wellventilated place.
Keep away from heat.
Protect from direct sunlight.
Protect from moisture.
Protect from frost.
Avoid contact with air/oxygen.
Advice on common storage : Never allow product to get in contact with water during storage.
Incompatible with oxidizing agents.
Do not store near acids.

Storage temperature :
0 - 30 °C


Specific end use(s)

Specific use(s) :
Reagent for organic synthesis., Transported isolated intermediate

Transport information

Land transport (ADR/RID)

UN number:
The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.

UN 1206
Proper shipping name and description:
Heptane
Chemical name:
n-Heptane
Language:
English
Class:
3
Classification code:
F1
Packaging group:
II
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
not applicable
Shippingopen allclose all
Class:
not applicable
Classification code:
not applicable
Packaging group:
not applicable
Labels:
not applicable
Remarks
No inland water transport

Marine transport (IMDG)

UN number:
The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.

UN 1206
Proper shipping name and description:
HEPTANES
Chemical name:
n-heptane
Class:
3
Packaging group:
II
EmS code:
F-E, S-D
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.

UN 1206
Proper shipping name and description:
Heptanes
Chemical name:
n-heptane
Class:
3
Packaging group:
II
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.



Components: n-Heptane
CAS-No.: 142-82-5
Value: TWA
Control parameters: 500 ppm
2,085 mg/m3
Update: 2000-06-16
Basis: 2000/39/EC
Further information: Indicative



Components: n-Heptane
CAS-No.: 142-82-5
Value: TWA
Control parameters: 500 ppm
Update: 2005-04-06
Basis: GB EH40
Further information: Where no specific short-term exposure limit is listed, a figure three times the long-term exposure
should be used


DNEL/DMEL
n-Heptane : End Use: Workers DNEL
Exposure routes: Skin contact
Potential health effects: Chronic effects, Systemic effects
Value: 300 mg/kg
End Use: Workers DNEL
Exposure routes: Inhalation
Potential health effects: Chronic effects, Systemic effects
Value: 2085 mg/m3

Stability and reactivity

The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.

Engineering measures

Provide sufficient air exchange and/or exhaust in work rooms.
Use product only in closed system.
Provide exhaust ventilation close to floor level.
Take precautionary measures against static discharges.
Electrical equipment should be protected to the appropriate standard.
Personal protective equipment

Respiratory protection:
In case of insufficient ventilation wear suitable respiratory equipment.
For short-time or low exposures, use breathing apparatus with a filter.

Recommended Filter type:
A-P2
For intensive or prolonged exposure, use a self-contained breathing apparatus.

Hand protection :
Glove material: Wear suitable gloves.
Protective gloves complying with EN 374. and:

Glove material:
Flame retardant gloves Protective gloves complying with EN 659.
The choice of an appropriate glove does not only depend on its material but also on other quality features and is different
The exact break through time can be obtained from the protective glove producer and this has to be observed.
Protective gloves have to be replaced at the first sign of deterioration.

Eye protection :
Eye protection (EN 166)
Tightly fitting safety goggles

Skin and body protection :
Flame retardant, antistatic and chemical resistant protective clothing

Hygiene measures :
Take off contaminated clothing and shoes immediately.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep away from food, drink and animal feedingstuffs.
Smoking, eating and drinking should be prohibited in the application area.
Wash hands before breaks and at the end of workday.

Protective measures :
Facilities storing or utilizing this material should be equipped
with an eyewash facility and safety shower.
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls

General advice :
Do not flush into surface water or sanitary sewer system.
Avoid subsoil penetration.

Disposal considerations

The following information applies to the substance in n-heptane (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents.

Product :
Dispose of in accordance with local regulations.
Contaminated packaging : Refer to manufacturer/supplier for information on recovery/recycling.

Waste Code : Waste codes should be assigned by the user, preferably in discussion with the waste disposal authorities.