Registration Dossier
Registration Dossier
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EC number: 203-518-7 | CAS number: 107-75-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (-)-perillaldehyde, (-)-myrtenal, cuminaldehyde, thujone, and (±)-carvone in rabbits
- Author:
- Ishida T., Toyota M. and Asakawa Y.
- Year:
- 1 989
- Bibliographic source:
- Xenobiotica, 19(8), 843-855
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- After test substance application, urine of rabbits was collected and analyzed to identify metabolites.
- GLP compliance:
- not specified
Test material
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): (±)-7-Hydroxycitronellal
- purchased from Nippon Terpene Chemistry Co. Ltd., and Shiono Koryo Kaisha Ltd., Japan
no further data given
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.0 kg
- Fasting period before study: 1 day
- Housing: in metabolism cages
- Diet and Water: ad libitum
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Tween-80 in water (0.02 g/100 mL)
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
- samples were homogenized in water (100 ml) with Tween-80 (0.02 g) at 5°C - Duration and frequency of treatment / exposure:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
about 6 g test substance per animal
- No. of animals per sex per dose / concentration:
- 6
- Control animals:
- not specified
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: daily for 3 days
- From how many animals: 6
- Method type(s) for identification: silica gel column chromatography, GC-FID/TCD
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- (±)-7-Hydroxycitronellol and 7-Hydroxycitronellic acid were identified in urine samples
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
