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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: case of occupational exposure
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Systemic Contact Allergy from Occupational Contact with Ethyl Ethoxymethylene Cyanoacetate
Year:
1992
Bibliographic source:
Contact Dermatitis, Vol.27, No. 1, pages 58-59, 6 references (TOXNET Toxicology Data Network)

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Principles of method if other than guideline:
No method following. This is a reported case of occupational exposure and sensitisation.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 2-cyano-3-ethoxyacrylate
EC Number:
202-299-5
EC Name:
Ethyl 2-cyano-3-ethoxyacrylate
Cas Number:
94-05-3
Molecular formula:
C8H11NO3
IUPAC Name:
ethyl 2-cyano-3-ethoxyacrylate

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 1
- Sex: man
- Other: worker on a pharmaceutical production line
Route of administration:
dermal

Results and discussion

Results of examinations:
The worker developed pruritic erythematous paches on his wrist after an initial exposure to the Ethyl Ethoxymethylene Cyanoacetate (EEMC). Subsequent exposure to vapor resulted in localized eczematous patches, generalized erythematous maculopapules, vesicles and erythema multiforme like eruptions on the face, neck and extremities.
Upon hospital admission, digital numbness, cold, clammy fingers, and hand tremor were seen. The patient was treated with systemic corticosteroids and antihistamines. A positive reaction to EEMC on patch tests was seen, and the examination of blood and urine specimens using high performance liquid chromatography demonstrated the presence of EEMC.
Virtually all of the symptoms resolved when the patient was transferred from the EEMC production line.

Applicant's summary and conclusion

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