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EC number: 222-182-2 | CAS number: 3380-34-5
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
- Principles of method if other than guideline:
- The solubility of Triclosan was determined by suspending an excess of the compound in the buffer and in the solvents n-hexane and n-octanol, andstirring the suspensions in a thermostatted water bath for 3 days. The concentration in the filtered solutions was then determined by HPLC analysis with a UV detector by the method of external calibration.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triclosan
- EC Number:
- 222-182-2
- EC Name:
- Triclosan
- Cas Number:
- 3380-34-5
- Molecular formula:
- C12H7Cl3O2
- IUPAC Name:
- 5-chloro-2-(2,4-dichlorophenoxy)phenol
Constituent 1
- Specific details on test material used for the study:
- - Substance type: organic
- Physical state: solid
- Lot/batch No.: 08246CL7 and 08454CL7
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- other: n-hexane
- Solubility:
- 16.6 g/kg solvent
- Temp.:
- 10 °C
- Medium:
- other: n-hexane
- Solubility:
- 31.5 g/kg solvent
- Temp.:
- 20 °C
- Medium:
- other: n-hexane
- Solubility:
- 63.2 g/kg solvent
- Temp.:
- 30 °C
- Medium:
- n-octanol
- Solubility:
- 52.1 g/kg solvent
- Temp.:
- 10 °C
- Medium:
- n-octanol
- Solubility:
- 48.1 g/kg solvent
- Temp.:
- 20 °C
- Medium:
- n-octanol
- Solubility:
- 55.6 g/kg solvent
- Temp.:
- 30 °C
Applicant's summary and conclusion
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