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Registration Dossier
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EC number: 202-870-9 | CAS number: 100-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No specific studies are available for assessment of the possible effect of N-methylaniline exposure on fertility. However, the repeated dose studies available (oral and inhalation), show no significant effects on reproductive organs of either male or female at concentrations that induce significant effects in the blood system and the target organ, the spleen. For aniline, a similar conclusion can be drawn. Therefore, no hazard is expected to be present for fertility at concentrations, which are at or below the NOEL(C) for repeated dose toxicity.
Effects on developmental toxicity
Description of key information
The key value is derived from key study with aniline and is supported by another developmental study with aniline and N,N-dimethylaniline. Considering the high rate of similarity in the mode of action between aniline and methylaniline, the value for N-methylaniline is copied from the study with aniline. A NOEL of 10 mg/kg/day was found for all embryotoxic, teratologic, and postnatal endpoints for the offspring.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
Additional information
Since aniline has proven to pass the placental barrier relatively easy, this is believed to be also true for N-methylaniline. Both substances are also easily absorbed by skin. Further, the type of route of exposure does not affect the mode of action of these anilines. Hence, here the NOAEL recorded for the teratological potential of aniline can be safely used as an estimated value for N-methylaniline.
Justification for classification or non-classification
Non-classification is based on the fact that N-methylaniline (and its impurities) does not affect fertility or embryonic or foetal development at concentrations, which induce significant toxicity in case of repeated dosing.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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