Registration Dossier
Registration Dossier
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EC number: 202-870-9 | CAS number: 100-61-8
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Collection of data by the Scientific Committee on Occupational Exposure Limits, a committee of the European Commission established in 1995 to advise on occupational exposure limits for chemicals in the workplace within the framework of Directive 98/24/EC, the chemical agents directive; and Directive 90/394/EEC, the carcinogens at work directive.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Handbook of Intermediary Metabolism of Aromatic CompoundsRecommendation from the Scientific Committee on Occupational Exposure Limits for N-methylaniline
- Author:
- Scientific Committee on Occupational Exposure Limits
- Year:
- 2 010
- Bibliographic source:
- Scientific Committee on Occupational Exposure Limits (SCOEL), SCOEL/SUM/178, September 2010.
Materials and methods
- Principles of method if other than guideline:
- Tests were performed before the existence of international guidelines, reference: Treon, J.F. et al., 1950. The toxic properties of xylidine and monomethylaniline II. Arch. of industrial hygiene & occupational medicine Vol. 1, pages: 506-524.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- N-methylaniline
- EC Number:
- 202-870-9
- EC Name:
- N-methylaniline
- Cas Number:
- 100-61-8
- Molecular formula:
- C7H9N
- IUPAC Name:
- N-methylaniline
Constituent 1
Test animals
- Species:
- other: Rabbits, rats, guinea pigs, cats, dogs and monkeys.
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: Not applicable.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Different durations of exposure.
- Frequency of treatment:
- 7h/d, 5d/week.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
- No. of animals per sex per dose:
- Not specified.
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- NOEC
- Effect level:
- 10.7 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Clinical signs of intoxication.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
