Registration Dossier
Registration Dossier
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EC number: 226-806-4 | CAS number: 5471-51-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-(4-hydroxyphenyl)butan-2-one
- EC Number:
- 226-806-4
- EC Name:
- 4-(4-hydroxyphenyl)butan-2-one
- Cas Number:
- 5471-51-2
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 4-(4-hydroxyphenyl)butan-2-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- human
Results and discussion
Any other information on results incl. tables
The negative control data meet the acceptance criteria if the mean OD value of the 3 tissues at 570 nm is:
1.2 < OD < 2.5 |
The positive control data meet the acceptance criteria if the mean viability, expressed as % of the NC, is <40%. |
In both cases, the standard deviation value will be considered valid if it is < 18% according to the performance standard (ECVAM SIVS, 2007)
optic density (OD) at 570 nm
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Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
